45762-41-2

Basic information

• Product Name: 4-BROMO-2-ETHYLANILINE
• Synonyms: 4-BROMO-2-ETHYLANILINE;4-BROMO-2-ETHYLANILINE: TECH.;BenzenaMine, 4-broMo-2-ethyl-;2-Ethyl-4-broMoaniline;Aniline, 4-broMo-2-ethyl- (7CI);4-Bromo-2-ethylaniline 96%
• CAS NO: 45762-41-2
• Molecular Formula: C₈H₁₀BrN
• Molecular Weight: 200.08
• EINECS: -0
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Amines;C8;Nitrogen Compounds
• Mol File: 45762-41-2.mol

Chemical Properties

• Boiling Point: 110-112°C 2mm
• Flash Point: 114 °F
• Appearance: /
• Density: 1.412 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.597(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.66±0.10(Predicted)
• BRN: 2802710
• CAS DataBase Reference: 4-BROMO-2-ETHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-ETHYLANILINE(45762-41-2)
• EPA Substance Registry System: 4-BROMO-2-ETHYLANILINE(45762-41-2)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39
• RIDADR: UN 1993 3/PG 1
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 45762-41-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-BROMO-2-ETHYLANILINE is used as a synthetic intermediate for the preparation of heteroaryl (arylamino)quinazoline derivatives, which have demonstrated in vitro antitumor activity. This makes it a valuable compound in the development of new and effective cancer treatments.

Upstream product

• 51688-73-4 N-(4-bromo-2-ethylphenyl)acetamide 
• 578-54-1 ortho-ethylaniline 
• 33098-65-6 2-acetamido-1-ethylbenzene 

Downstream Products

• 81090-37-1 4-bromo-N,2-diethylaniline 
• 89980-75-6 1-Aethyl-2-amino-5-brom-4-nitro-benzol 
• 1026474-15-6 (E)-2-Acetylamino-3-(4-amino-3-ethyl-phenyl)-acrylic acid methyl ester 
• 436864-41-4 benzyl (2E)-2-(acetylamino)-3-(4-amino-3-ethylphenyl)-2-propenoate 
• 765948-87-6 4-(4-amino-3-ethylphenyl)-1-isoindolinone 
• 402924-97-4 2-acetylamino-3-(4-amino-3-ethyl-phenyl)-propionic acid 
• 89978-51-8 4-Nitro-3-brom-ethylbenzol 
• 749928-94-7 N-(4-bromo-2-ethyl-phenyl)-methanesulfonamide 
• 849630-53-1 N-(4-bromo-2-ethylphenyl)-2-(hydroxyimino)acetamide 
• 552331-16-5 5-bromo-3-methyl-1H-indazole 
• 51688-73-4 N-(4-bromo-2-ethylphenyl)acetamide 
• 175278-30-5 1-iodo-2-ethyl-4-bromobenzene 
• 1160929-94-1 N-(4-bromo-2-ethylphenyl)-2-isopropoxy-6-pentadecylbenzamide 
• 1160929-75-8 N-(4-bromo-2-ethylphenyl)-2-ethoxy-6-pentadecylbenzamide 

Relevant articles and documents

Donor-substituted distyrylpyrazines: Influence of steric congestion on UV-Vis absorption and fluorescence

Di(p-aminostyryl)pyrazines with voluminous substituents on the nitrogen and in the adjacent positions were prepared via twofold aldol condensation. Absorption and emission spectra are influenced by increasing steric hindrance because the orbital overlap between nitrogen and π-system is modulated by voluminous groups. Strong solvatochromism of the fluorescence and huge Stokes shifts result from amplified donor-acceptor interaction in the excited state. Protonation occurs at the terminal amino groups first, followed by protonation of the central pyrazine. With increasing strength of acid, absorption and emission spectra are first shifted to the blue followed by a redshift. Copyright

Para-bromination of ortho-alkyl anilines

A process of selectively preparing p-bromo-o-alkylanilines (e.g. 4-bromo-2-methylaniline) by reacting o-alkylanilines (e.g., 2-methylaniline) with unadsorbed bromine in a solvent selected from the group consisting of an inert di- tri- or tetrahaloaliphatic hydrocarbon (e.g., dichloromethane and dibromomethane), an alkyl nitrile (e.g., acetonitrile) and mixtures thereof.