765948-87-6

Usage

Molecular Weight

255.32 g/mol

Structure

A heterocyclic organic compound with a ring structure containing both nitrogen and oxygen atoms, and a dihydro-2,3-phenethylamine substituent.

Class

Isoindolones

Derivative

A derivative of isoindoline

Usage

Used in organic synthesis and pharmaceutical research

Properties

Valuable compound in the field of chemical and medicinal sciences due to its potential applications.

Upstream product

• 337536-15-9 4-bromo-2,3-dihydro-isoindol-1-one 
• 21900-48-1 3-bromo-2-methylbenzoic acid chloride 
• 99548-54-6 methyl 3-bromo-2-methylbenzoate 
• 45762-41-2 4-bromo-2-ethylaniline 
• 765948-78-5 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one 
• 337536-14-8 methyl 3-bromo-2-(bromomethyl)benzoate 
• 76006-33-2 3-bromo-2-methylbenzoic acid 

Relevant academic research and scientific papers

Isoindolinone kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

ISOINDOLIN-1-ONE COMPOUNDS AS KINASE INHIBITORS

Compounds having the formula, (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds and compositions containing the compounds.

Isoindolinone ureas: A novel class of KDR kinase inhibitors

A series of substituted isoindolinone ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 14c, are potent inhibitors of KDR both enzymatically (50nM) and cellularly (≤100nM). A 3D KDR/CDK2/MAP kinase overlay model with several structurally related tyrosine kinase inhibitors was used to predict the binding interactions of the isoindolinone ureas with the KDR active site.