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L-Proline, 4-hydroxy-4-methyl-, (4S)- (9CI) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 459457-01-3 Structure
  • Basic information

    1. Product Name: L-Proline, 4-hydroxy-4-methyl-, (4S)- (9CI)
    2. Synonyms: L-Proline, 4-hydroxy-4-methyl-, (4S)- (9CI)
    3. CAS NO:459457-01-3
    4. Molecular Formula: C6H11NO3
    5. Molecular Weight: 145.15644
    6. EINECS: N/A
    7. Product Categories: ALCOHOL;CARBOXYLICACID
    8. Mol File: 459457-01-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: L-Proline, 4-hydroxy-4-methyl-, (4S)- (9CI)(CAS DataBase Reference)
    10. NIST Chemistry Reference: L-Proline, 4-hydroxy-4-methyl-, (4S)- (9CI)(459457-01-3)
    11. EPA Substance Registry System: L-Proline, 4-hydroxy-4-methyl-, (4S)- (9CI)(459457-01-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 459457-01-3(Hazardous Substances Data)

459457-01-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 459457-01-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,9,4,5 and 7 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 459457-01:
(8*4)+(7*5)+(6*9)+(5*4)+(4*5)+(3*7)+(2*0)+(1*1)=183
183 % 10 = 3
So 459457-01-3 is a valid CAS Registry Number.

459457-01-3Downstream Products

459457-01-3Relevant articles and documents

Evolution of Biocatalytic and Chemocatalytic C-H Functionalization Strategy in the Synthesis of Manzacidin C

Zwick, Christian R.,Renata, Hans

, p. 7407 - 7415 (2018/05/29)

Because of their unique molecular architecture, the manzacidins have been the subject of intense synthetic efforts in the past two decades. Here, we describe two synthetic approaches toward manzacidin C that center on the enzymatic hydroxylation of unprotected l-leucine. This study also resulted in the discovery of novel synthetic methodologies, including a photocatalytic C-H azidation of unprotected amino acids. Additionally, we describe the use of hydroxylated l-leucine in the preparation of various densely substituted pyrrolidines.

Remote C-H Hydroxylation by an α-Ketoglutarate-Dependent Dioxygenase Enables Efficient Chemoenzymatic Synthesis of Manzacidin C and Proline Analogs

Zwick, Christian R.,Renata, Hans

supporting information, p. 1165 - 1169 (2018/02/07)

Selective C-H functionalization at distal positions remains a highly challenging problem in organic synthesis. Though Nature has evolved a myriad of enzymes capable of such feat, their synthetic utility has largely been overlooked. Here, we functionally characterize an α-ketoglutarate-dependent dioxygenase (Fe/αKG) that selectively hydroxylates the ? position of various aliphatic amino acids. Kinetic analysis and substrate profiling of the enzyme show superior catalytic efficiency and substrate promiscuity relative to other Fe/αKGs that catalyze similar reactions. We demonstrate the practical utility of this transformation in the concise syntheses of a rare alkaloid, manzacidin C, and densely substituted amino acid derivatives with remarkable step efficiency. This work provides a blueprint for future applications of Fe/αKG hydroxylation in complex molecule synthesis and the development of powerful synthetic paradigms centered on enzymatic C-H functionalization logic.

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