Organocatalytic enantioselective oxidative C-H alkenylation and arylation of N-Carbamoyl tetrahydropyridines and tetrahydro-β-carbolines
The first organocatalytic enantioselective C-H alkenylation and arylation reactions of N-carbamoyl tetrahydropyridines and tetrahydro-β-carbolines (THCs) are described. The metal-free processes represent an efficient and straightforward approach to a variety of structurally and electronically diverse α-substituted tetrahydropyridines and THCs in good yields with excellent regio- and enantioselectivities. Preliminary control experiments provide important insights into the reaction mechanism.
Liu, Xigong,Meng, Zhilin,Li, Chengkun,Lou, Hongxiang,Liu, Lei
p. 6012 - 6015
(2015/05/13)
REACTION OF 1-CARBAMOYL-3,4-EPOXY-4-PHENYLPIPERIDINES WITH LEWIS ACIDS
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Hershenson, Fred M.,Christensen, Leif
p. 615 - 626
(2007/10/02)
Studies on Psychotropic Agents. VI. Synthesis of 1'-Methylspiro-3-one and Related Compounds
The title compounds (19) were synthesized by rearrangement of the 1-ethoxycarbonyl-4-aryl-3,4-epoxypiperidines (7) to give the 3-aryl-3-formylpyrrolidine derivatives (12) for pharmacological testing.Compound (19b) exhibited moderate central nervous system