467470-43-5

Basic information

• Product Name: 1H-Pyrrole-2-carbonitrile, 4-acetyl-3,5-dimethyl- (9CI)
• Synonyms: 1H-Pyrrole-2-carbonitrile, 4-acetyl-3,5-dimethyl- (9CI)
• CAS NO: 467470-43-5
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.1885
• Product Categories: ACETYLGROUP
• Mol File: 467470-43-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrole-2-carbonitrile, 4-acetyl-3,5-dimethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carbonitrile, 4-acetyl-3,5-dimethyl- (9CI)(467470-43-5)
• EPA Substance Registry System: 1H-Pyrrole-2-carbonitrile, 4-acetyl-3,5-dimethyl- (9CI)(467470-43-5)

Safety Data

• Hazardous Substances Data: 467470-43-5(Hazardous Substances Data)

Upstream product

• 123-54-6 acetylacetone 
• 4513-92-2 3,5-dimethyl-1H-pyrrole-2-carbonitrile 
• 75-36-5 acetyl chloride 

Downstream Products

• 467470-45-7 4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxamide 

Relevant articles and documents

Discovery of n-phenyl-4-(1h-pyrrol-3-yl)pyrimidin-2-amine derivatives as potent mnk2 inhibitors: Design, synthesis, sar analysis, and evaluation of in vitro anti-leukaemic activity

Background: Aberrant expression of eukaryotic translation initiation factor 4E (eIF4E) is common in many types of cancer including acute myeloid leukaemia (AML). Phosphorylation of eIF4E by MAPK-interacting kinases (Mnks) is essential for the eIF4E-mediated oncogenic activity. As such, the pharmacological inhibition of Mnks can be an effective strategy for the treatment of cancer. Methods: A series of N-phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine derivatives was designed and synthesised. The Mnk inhibitory activity of these derivatives as well as their anti-proliferative activity against MV4-11 AML cells was determined. Results: These compounds were identified as potent Mnk2 inhibitors. Most of them demonstrated potent anti-proliferative activity against MV4-11 AML cells. The cellular mechanistic studies of the representative inhibitors revealed that they reduced the level of phosphorylated eIF4E and induced apoptosis by down-regulating the anti-apoptotic protein myeloid cell leukaemia 1 (Mcl-1) and by cleaving poly(ADP-ribose)polymerase (PARP). The lead compound 7k possessed desirable pharmacokinetic properties and oral bioavailability. Conclusion: This work proposes that exploration of the structural diversity in the context of N-phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine would offer potent and selective Mnk inhibitors.

Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors

A series of 2-anilino-4-(1H-pyrrol-3-yl)pyrimidines were prepared and evaluated for their ability to inhibit cyclin-dependent kinases (CDKs). A number of analogues were found to be potent CDK2 and CDK4 inhibitors and to exhibit anti-proliferative activity