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468740-43-4

Insulin-like Growth Factor-1 Receptor Inhibitor, also known as BMS 536924, is a pharmaceutical compound that acts as an inhibitor of insulin-like growth factor receptor (IGF1R) kinase and insulin receptor. It is a promising agent in the field of oncology due to its potential to target and inhibit the activity of IGF1R, which plays a crucial role in cell growth, proliferation, and survival.
Used in Oncology:
Insulin-like Growth Factor-1 Receptor Inhibitor is used as an antitumor agent for its ability to target and inhibit the IGF1R kinase and insulin receptor, thereby disrupting the signaling pathways that promote tumor growth and progression. BMS 536924 has been reported to exhibit antitumor activity, making it a potential therapeutic option for cancer treatment.
Used in Drug Development:
Insulin-like Growth Factor-1 Receptor Inhibitor is used as a research tool in the development of novel cancer therapies. By understanding the mechanism of action and potential synergistic effects of BMS 536924 with other drugs, researchers can design more effective treatment strategies and drug combinations to target cancer cells while minimizing side effects.
Used in Cancer Research:
Insulin-like Growth Factor-1 Receptor Inhibitor is used as a research compound to study the role of IGF1R in cancer biology. By investigating the effects of BMS 536924 on various cancer cell lines and tumor models, researchers can gain insights into the molecular mechanisms underlying the regulation of cell growth, proliferation, and survival, as well as identify potential biomarkers and therapeutic targets for cancer treatment.

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  • 4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-3H-1,3-benzodiazol-2-yl]-1H-pyridin-2-one

    Cas No: 468740-43-4

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  • 468740-43-4 Structure

  • Basic information

    1. Product Name: Insulin-like Growth Factor-1 Receptor Inhibitor
    2. Synonyms: 4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone;BMS-536924;Insulin-like Growth Factor-1 Receptor Inhibitor;4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]aMino]-3-[7-Methyl-5-(4-Morpholinyl)-1H-benziMidazol-2-yl]-2(1H)-pyridinone BMS-536924;4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-(4-morpholinyl)-1H-benzimidazol-2-yl]- 2(1H)-pyridinone;CS-0117;HY-10262;BMS-536924 Insulin-like Growth Factor-1 Receptor Inhibitor
    3. CAS NO:468740-43-4
    4. Molecular Formula: C25H26ClN5O3
    5. Molecular Weight: 479.95864
    6. EINECS: N/A
    7. Product Categories: Inhibitors
    8. Mol File: 468740-43-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.44
    6. Refractive Index: 1.717
    7. Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
    8. Solubility: DMSO (Slightly)
    9. PKA: 10.40±0.10(Predicted)
    10. CAS DataBase Reference: Insulin-like Growth Factor-1 Receptor Inhibitor(CAS DataBase Reference)
    11. NIST Chemistry Reference: Insulin-like Growth Factor-1 Receptor Inhibitor(468740-43-4)
    12. EPA Substance Registry System: Insulin-like Growth Factor-1 Receptor Inhibitor(468740-43-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 468740-43-4(Hazardous Substances Data)

468740-43-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 468740-43-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,6,8,7,4 and 0 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 468740-43:
(8*4)+(7*6)+(6*8)+(5*7)+(4*4)+(3*0)+(2*4)+(1*3)=184
184 % 10 = 4
So 468740-43-4 is a valid CAS Registry Number.
InChI:InChI=1/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1

468740-43-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-4-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-3-(4-methyl-6-morpholin-4-yl-1H-benzoimidazol-2-yl)-1H-pyridin-2-one

1.2 Other means of identification

Product number -
Other names 4-[[(2S)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO]-3-[7-METHYL-5-(4-MORPHOLINYL)-1H-BENZIMIDAZOL-2-YL]-2(1H)-PYRIDINONE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:468740-43-4 SDS

468740-43-4Downstream Products

468740-43-4Relevant articles and documents

Discovery of a 1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity

Wittman, Mark,Carboni, Joan,Attar, Ricardo,Balasubramanian, Balu,Balimane, Praveen,Brassil, Patrick,Beaulieu, Francis,Chang, Chiehying,Clarke, Wendy,Dell, Janet,Eummer, Jeffrey,Frennesson, David,Gottardis, Marco,Greer, Ann,Hansel, Steven,Hurlburt, Warren,Jacobson, Bruce,Krishnananthan, Subramaniam,Lee, Francis Y.,Li, Aixin,Lin, Tai-An,Liu, Peiying,Ouellet, Carl,Sang, Xiaopeng,Saulnier, Mark G.,Stoffan, Karen,Sun, Yax,Velaparthi, Upender,Wong, Henry,Yang, Zheng,Zimmermann, Kurt,Zoeckler, Mary,Vyas, Dolatrai

, p. 5639 - 5643 (2007/10/03)

Compound 3 (BMS-536924), a novel small-molecule inhibitor of the insulin-like growth factor receptor kinase with equal potency against the insulin receptor is described. The in vitro and in vivo biological activity of this interesting compound is also rep

Novel tyrosine kinase inhibitors

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Page 179, (2010/11/30)

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inhibiting tyrosine kinase enzymes.

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