CAS No.468740-43-4,Insulin-like Growth Factor-1 Receptor Inhibitor Suppliers

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Basic Information

Molecular Structure:
CAS No.:	468740-43-4
Name:	Insulin-like Growth Factor-1 Receptor Inhibitor
Article Data:	2

Formula:	C₂₅H₂₆ClN₅O₃
Molecular Weight:	479.966
Synonyms:	4-{[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino}-3-(4-methyl-6-morpholin-4-yl-1H-benzimidazol-2-yl)pyridin-2(1H)-one;
Density:	1.44 g/cm³
PSA:	106.27000
LogP:	4.00010

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Specification

The Insulin-like growth factor-1 receptor inhibitor, with the CAS registry number of 468740-43-4, is also known as BMS-536924. This chemical's molecular formula is C₂₅H₂₆ClN₅O₃ and molecular weight is 479.96. What's more, its systematic name is called 4-{[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino}-3-(4-methyl-6-morpholin-4-yl-1H-benzimidazol-2-yl)pyridin-2(1H)-one. In addition, it is a protein that in humans is encoded by the IGF1 gene. And it has also been referred to as a "sulfation factor" and its effects were termed "nonsuppressible insulin-like activity" (NSILA) in the 1970s. Besides, this chemical is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. It can be used as diagnostic test and therapeutic agent.

Physical properties about Insulin-like growth factor-1 receptor inhibitor are: (1)ACD/LogP: 2.61; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.28; (4)ACD/LogD (pH 7.4): 2.5; (5)ACD/BCF (pH 5.5): 2.63; (6)ACD/BCF (pH 7.4): 44.34; (7)ACD/KOC (pH 5.5): 29.08; (8)ACD/KOC (pH 7.4): 489.83; (9)#H bond acceptors: 8; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 102.51 Å²; (13)Index of Refraction: 1.717; (14)Molar Refractivity: 130.96 cm³; (15)Molar Volume: 332.4 cm³; (16)Surface Tension: 77.2 dyne/cm; (17)Density: 1.44 g/cm³.

You can still convert the following datas into molecular structure:
(1) SMILES: Clc1cccc(c1)[C@H](O)CNC=2/C=C\NC(=O)C=2c5nc3c(cc(cc3C)N4CCOCC4)n5
(2) InChI: InChI=1/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1
(3) InChIKey: ZWVZORIKUNOTCS-OAQYLSRUBW