- Synthesizing method of oxidized dicentrine
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The invention discloses a synthesizing method of oxidized dicentrine. The synthesizing method comprises the following steps of using 3,4-dimethoxyphenylacetic acid as the start raw material, reactingwith bromine to obtain a product, and then reacting with
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Paragraph 0042-0045
(2019/03/28)
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- Oxidized dicentra spectabilis alkali rare earth compound as well as synthesis method and application thereof
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The invention discloses an oxidized dicentra spectabilis alkali rare earth compound as well as a synthesis method and application thereof. The rare earth compound is obtained by dissolving oxidized dicentra spectabilis alkali and rare earth metal salt int
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Paragraph 0025; 0028-0030
(2019/02/25)
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- Bromated oxidated dicentrine and synthesis method and application thereof
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The invention discloses bromated oxidated dicentrine and a synthesis method and application thereof. The synthesis method of the bromated oxidated dicentrine comprises the steps of subjecting 3,4-dimethoxyphenylacetic acid, which serves as a starting raw
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Paragraph 0048-0051
(2019/04/04)
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- In order to bromo ligand dutch bud peony alkali oxide of the rare earth complex and its synthetic method and application (by machine translation)
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The invention discloses a dutch bud peony alkali as ligand to bromo oxidation of the rare earth complex and its synthetic method and application. The rare earth complex is to bromo dutch bud peony alkali oxide and a rare earth metal salt in the solvent sy
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Paragraph 0060-0062
(2019/05/08)
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- Enantioselective synthesis and anti-parasitic properties of aporphine natural products
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Chagas disease and visceral leishmaniasis are neglected protozoan diseases with significant impact in developing countries. Due to the limited number and toxicity of current therapies, new drug leads are urgently needed. In this work, four aporphine natural products were synthesized using an enantioselective, modular and convergent strategy, comprising eight steps in the longest linear sequence; key steps included Bischler-Napieralski cyclization/Noyori asymmetric reduction to construct the tetrahydroisoquinolines, and palladium-catalyzed arylation to close the C ring. Norglaucine, nordicentrine and dicentrine showed promising bioactivity against T. cruzi and L. infantum, suggesting potential for further development of these scaffolds as antiparasitic agents.
- Amaral, Maiara,Anderson, Edward A.,McHugh, Eliza,Pieper, Pauline,Tempone, Andre G.
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- Copper-catalyzed intramolecular cross dehydrogenative coupling approach to coumestans from 2′-hydroxyl-3-arylcoumarins
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A copper-catalyzed intramolecular cross dehydrogenative C-O coupling reaction of 2′-hydroxyl-3-arylcoumarins was developed. This protocol provided a facile and efficient strategy for the construction of natural coumestans and derivatives in moderate to high yields. This transformation exhibited good functional group compatibility and was amenable to substrates with free phenolic hydroxyl groups.
- Song, Xianheng,Luo, Xiang,Sheng, Jianfei,Li, Jianheng,Zhu, Zefeng,Du, Zhibo,Miao, Hui,Yan, Meng,Li, Mingkang,Zou, Yong
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p. 17391 - 17398
(2019/06/24)
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- The palladium-catalyzed preparation of condensed tetracyclic heterocycles and their application to the synthesis of rac-mangochinine
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Dihydroisoquinoline derivatives and their analogues, prepared by the Bischler-Napieralsky reaction, were converted to their indole-fused derivatives. Scope and limitations of the palladium-catalyzed reaction, proceeding through the tautomeric enamine forms of these compounds, were studied and the process was extended to the preparation of racemic mangochinine. Georg Thieme Verlag Stuttgart.
- Vincze, Zoltan,Biro, A. Beatrix,Csekei, Marton,Timari, Geza,Kotschy, Andras
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p. 1375 - 1385
(2007/10/03)
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- Revisiting the Ullmann-ether reaction: A concise and amenable synthesis of novel dibenzoxepino[4,5-d]pyrazoles by intramolecular etheration of 4,5-(o,o′-halohydroxy)arylpyrazoles
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A concise synthesis of a series of novel dibenzoxepino[4,5-d]pyrazoles was accomplished by implementation of an intramolecular Ullmann-ether reaction on o,o'-halohydroxy-4,5-diarylpyrazoles mediated by CuBr·DMS. An alternative useful approach based on the palladium-catalyzed biarylether linkage formation (Buchwald-Hartwig reaction) was also successfully applied, offering limitations with regard to the steric demand of the substituents. The synthesis of the key o,o′-halohydroxy-4,5-diarylpyrazole intermediates proceeds through the construction of the heterocyclic ring by a tandem amine-exchange/heterocyclization sequence of 3-N,N-(dimethylamino)-1,2-diarylpropenones with phenylhydrazine followed by basic hydrolysis for deprotection. The enamino ketone precursors were conveniently prepared from the corresponding O-sulfonyloxy and O-benzoyloxy ortho-substituted 1,2-diarylethanones, starting from inexpensive salicylaldehyde or phenylacetic derivatives. Preliminary binding affinity experiments against peripheral and central nervous system receptors have been done with negative results.
- Olivera, Roberto,SanMartin, Raul,Churruca, Fatima,Dominguez, Esther
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p. 7215 - 7225
(2007/10/03)
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- Bischler-napieralski reaction of n-[2-(2-bromo-4,5-dialkyloxyphenyl)ethyl]-n-(1-phenylethyl)-2- (2-bromo-4,5-dimethoxyphenyl)acetamides
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Direction of Bischler-Napieralski reaction of N-[2-(2-bromo- or 2-unsubstituted 4,5-dialkoxyphenyl)ethyl]-N-(1-phenylethyl)-2- (2-bromo-4,5-dimethoxyphenyl)acetamides is discussed.
- Hashimoto, Naomi,Miyatani, Kumiko,Ohkita, Keiko,Ohishi, Yoshitaka,Kunitomo, Jun-Ichi,Kawasaki, Ikuo,Yamashita, Masayuki,Ohta, Shunsaku
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p. 2149 - 2161
(2007/10/03)
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- Chloromethylation of 2-Bromo-4,5-dimethoxyphenylacetic Acid : Formation of 6,7-Dimethoxy-3-isochromanone
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Prolonged treatment of 2-bromo-4,5-dimethoxyphenylacetic acid (1) with 37percent formalin and hydrochloric acid in acetic acid affords 6,7-dimethoxy-3-isochromanone (4) resulting from the loss of the bromo substituent.The recently reported formation of 5,
- Nimgirawath, S.,Srikirin, Y.
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p. 272 - 273
(2007/10/02)
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- Synthesis of 5,6-Dibromo-7,8-dimethoxyisochroman-3-one from 2-Bromohomoveratric Acid
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An unusual reaction of 2-bromo-4,5-dimethoxyphenylacetic acid (2), prepared by the action of bromine on homoveratric acid (1), is reported.The reaction of 2 with 37percent formalin and HCl in gl.AcOH instead of yielding the expected 5-bromo-7,8-dimethoxyi
- Pandey, G. D.,Tiwari, K. P.
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