- C-20 STEROID COMPOUNDS, COMPOSITIONS AND USES THEREOF TO TREAT TRAUMATIC BRAIN INJURY (TBI), INCLUDING CONCUSSIONS
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The present invention relates to C-20 steroid compounds, compositions and methods of use thereof to treat, minimize and/or prevent traumatic brain injury (TBI), including severe TBI, moderate TBI and mild TBI, including concussions.
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- Process for the preparation of steroid oxiranes
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Steroids containing both an isolated and an α,β-unsaturated keto group are selectively reacted with dimethyl sulfonium methylide in a non-reactive polar solvent and in the presence of an alkali tertiary alcoholate to produce α,β-unsaturated keto steroids containing the group EQU1
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