472-54-8

Basic information

• Product Name: 19-NORPROGESTERONE
• Synonyms: 19-NORPROGESTERONE;19-NOR-4-PREGNEN-3,20-DIONE;19-nor-p;19-norpregn-4-ene-3,20-dione
• CAS NO: 472-54-8
• Molecular Formula: C20H28O2
• Molecular Weight: 300.44
• Product Categories: Hormones;Progesterone;Steroid Hormones
• Mol File: 472-54-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 144.5°C
• Boiling Point: 381.66°C (rough estimate)
• Flash Point: 166.8°C
• Appearance: off-white/powder
• Density: 1.0597 (rough estimate)
• Vapor Pressure: 3.38E-08mmHg at 25°C
• Refractive Index: 1.4800 (estimate)
• Water Solubility: 36.1mg/L(37 oC)
• CAS DataBase Reference: 19-NORPROGESTERONE(CAS DataBase Reference)
• NIST Chemistry Reference: 19-NORPROGESTERONE(472-54-8)
• EPA Substance Registry System: 19-NORPROGESTERONE(472-54-8)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: RC8960500
• Hazardous Substances Data: 472-54-8(Hazardous Substances Data)

Usage

Uses

19-Norprogesterone is a close analogue of the steroid progesterone.

Safety Profile

Experimental reproductiveeffects. Questionable carcinogen with experimentaltumorigenic and teratogenic data. When heated todecomposition it emits acrid smoke and irritating fumes

InChI:InChI=1/C20H28O2/c1-12(21)18-7-8-19-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h11,15-19H,3-10H2,1-2H3/t15-,16+,17+,18+,19-,20+/m0/s1

Upstream product

• 65078-08-2 (Z)-3,20-dimethoxy-21-hydroxy-19-norpregna-1,3,5⁽¹⁰⁾,17⁽²⁰⁾-tetraene 
• 27428-41-7 3-oxo-7,7-(ethylenedioxy)-octanoic acid ethyl ester 
• 16271-49-1 (1S,7aS)-1-hydroxy-7a-methyl-2,3,7,7a-tetrahydro-1H-inden-5(6H)-one 
• 17553-86-5 (S)-Halos-Parish ketone 
• 13886-12-9 C₂₀H₃₀O₃ 
• 434-22-0 19-nortestosterone 
• 24157-07-1 3β-tertiarybutoxy-1,2,3,3a,4,5,8,9,9aβ, 9bα-decahydro-6-[2-(2-methyl-1,3-dioxolan-2-yl)-ethyl]-3aβ-methyl-7H-benz[e]inden-7-one 
• 41878-38-0 (1S,7aS)-1-tert-butoxy-7a-methyl-1,2,3,6,7,7a-hexahydro-5H-inden-5-one 
• 66964-58-7 17-acetoxy-19-nor-17βH-pregn-4-ene-3,20-dione 
• 51-98-9 norethisterone acetate 
• 74824-58-1 17-cyanoestra-4,16-dien-3-one 
• 17006-06-3 17-hydroxy-17-cyanoestr-4-en-3-one 
• 68574-72-1 (Z)-methyl 3,20-dimethoxy-19-norpregna-1,3,5⁽¹⁰⁾,17⁽²⁰⁾-tetraen-21-oate 
• 1624-62-0 estrone 3-methyl ether 

Downstream Products

• 1667-98-7 3-hydroxy-19-norpregna-1,3,5⁽¹⁰⁾-trien-20-one 
• 4772-11-6 20α_F-hydroxy-19-nor-pregn-4-en-3-one 
• 3643-00-3 20β-hydroxy-19-nor-4-pregnen-3-one 
• 4682-70-6 19-Nordeoxycorticosterone 
• 21513-89-3 Δ^3,5-19-Norpregnadien-20-on 

Relevant articles and documents

C-20 STEROID COMPOUNDS, COMPOSITIONS AND USES THEREOF TO TREAT TRAUMATIC BRAIN INJURY (TBI), INCLUDING CONCUSSIONS

The present invention relates to C-20 steroid compounds, compositions and methods of use thereof to treat, minimize and/or prevent traumatic brain injury (TBI), including severe TBI, moderate TBI and mild TBI, including concussions.

Synthesis of 19-norprogesterone and 19-nordeoxycorticosterone

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