473452-26-5

Basic information

• Product Name: Carbamic acid, [(1S)-1-formyl-2-hydroxy-2-methylpropyl]-, 1,1-dimethylethyl
• Synonyms: Carbamic acid, [(1S)-1-formyl-2-hydroxy-2-methylpropyl]-, 1,1-dimethylethyl
• CAS NO: 473452-26-5
• Molecular Formula: C10H19NO4
• Molecular Weight: 217.26216
• Product Categories: N-BOC
• Mol File: 473452-26-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, [(1S)-1-formyl-2-hydroxy-2-methylpropyl]-, 1,1-dimethylethyl(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-1-formyl-2-hydroxy-2-methylpropyl]-, 1,1-dimethylethyl(473452-26-5)
• EPA Substance Registry System: Carbamic acid, [(1S)-1-formyl-2-hydroxy-2-methylpropyl]-, 1,1-dimethylethyl(473452-26-5)

Safety Data

• Hazardous Substances Data: 473452-26-5(Hazardous Substances Data)

Upstream product

• 473545-40-3 tert-butyl N-[(1R)-2-hydroxy-1-(hydroxymethyl)-2-methylpropyl]carbamate 
• 126181-46-2 (2R)-methyl 2-((tert-butoxycarbonyl)amino)-3-((tetrahydro-2H-pyran-2-yl)oxy)propanoate 
• 95715-85-8 2-(tert-butoxycarbonylamino)-3-hydroxypropionic acid methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 473452-22-1 methyl (S)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-methylbutanoate 
• 102507-13-1 N-(tert-butoxycarbonyl)-3-hydroxy-L-valine 

Downstream Products

• 59979-01-0 thiocillin I 

Relevant articles and documents

Total synthesis and complete structural assignment of thiocillin i

The total synthesis of the thiopeptide antibiotic, thiocillin I, is described. This work unequivocally defines the full structure (constitution and configuration) of the natural product as 1.

Poly(vinyl alcohol)-graft-poly(ethylene glycol) resins and their use in solid-phase synthesis and supported TEMPO catalysis

New poly(vinyl alcohol)-graft-poly(ethylene glycol) (PVA-g-PEG) resins with various PEG chain lengths, which have high loadings and good swelling both in water and organic solvents, have been prepared via an anionic polymerization of ethylene oxide onto PVA beads and applied in solid-phase synthesis, supported TEMPO catalysis and in HR-MAS 1H NMR spectral analysis. The Royal Society of Chemistry.

A synthesis of a hydroxyvaline-derived thiazole-4-carboxylate constituting an antibiotic, thiocilline I

A convenient synthesis of an important constituent segment, methyl (2S)-2-[1-(N-Boc)amino-2-hydroxy-2-methyl]propylthiazole-4-carboxylate (2), which is the Fragment C derivative of a macrocyclic antibiotic, thiocilline, is described. Reduction of methyl N-Boc-hydroxyvalinate (4) with NaBH4, followed by oxidation with Dess-Martin reagent gave the corresponding formyl derivative, which was then thiazolated with H-L-Cys-OMe to give 2.