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44-O-DeMethylthiocillin II is a derivative of the macrocyclic thiazole peptide Thiocillin I, which was first isolated from Bacillus badius. It is a simple macrocyclic thiazole peptide with a modified structure, where the methyl group at the 44th position has been removed.

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  • 59979-01-0 Structure
  • Basic information

    1. Product Name: 44-O-DeMethylthiocillin II
    2. Synonyms: 44-O-DeMethylthiocillin II;Thiocillin I
    3. CAS NO:59979-01-0
    4. Molecular Formula: C48H49N13O10S6
    5. Molecular Weight: 1160.3738
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 59979-01-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 44-O-DeMethylthiocillin II(CAS DataBase Reference)
    10. NIST Chemistry Reference: 44-O-DeMethylthiocillin II(59979-01-0)
    11. EPA Substance Registry System: 44-O-DeMethylthiocillin II(59979-01-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 59979-01-0(Hazardous Substances Data)

59979-01-0 Usage

Uses

Used in Pharmaceutical Industry:
44-O-DeMethylthiocillin II is used as a potent antibacterial agent for the development of new antibiotics. Its modified structure may enhance its biological activity and effectiveness against various bacterial strains.
Used in Research and Development:
44-O-DeMethylthiocillin II is used as a research compound for studying the structure-activity relationship of macrocyclic thiazole peptides and their potential applications in medicine. This can lead to the discovery of new therapeutic agents with improved properties.

Check Digit Verification of cas no

The CAS Registry Mumber 59979-01-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,9,7 and 9 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 59979-01:
(7*5)+(6*9)+(5*9)+(4*7)+(3*9)+(2*0)+(1*1)=190
190 % 10 = 0
So 59979-01-0 is a valid CAS Registry Number.

59979-01-0Upstream product

59979-01-0Downstream Products

59979-01-0Relevant articles and documents

Total synthesis of micrococcin P1 and thiocillin I enabled by Mo(vi) catalyst

Akasapu, Siddhartha,Hinds, Aaron B.,Powell, Wyatt C.,Walczak, Maciej A.

, p. 1971 - 1975 (2019/02/20)

Thiopeptides are a class of potent antibiotics with promising therapeutic potential. We developed a novel Mo(vi)-oxide/picolinic acid catalyst for the cyclodehydration of cysteine peptides to form thiazoline heterocycles. With this powerful tool in hand,

Total synthesis and complete structural assignment of thiocillin i

Aulakh, Virender S.,Ciufolini, Marco A.

, p. 5900 - 5904 (2011/06/10)

The total synthesis of the thiopeptide antibiotic, thiocillin I, is described. This work unequivocally defines the full structure (constitution and configuration) of the natural product as 1.

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