475042-38-7

Basic information

• Product Name: 6-CHLOROMETHYL-4-(4-METHOXY-PHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: AKOS B022865;AKOS BC-3109;6-CHLOROMETHYL-4-(4-METHOXY-PHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER;ETHYL 6-(CHLOROMETHYL)-4-(4-METHOXYPHENYL)-2-OXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE;ART-CHEM-BB B022865
• CAS NO: 475042-38-7
• Molecular Formula: C₁₅H₁₇ClN₂O₄
• Molecular Weight: 324.76
• Mol File: 475042-38-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-CHLOROMETHYL-4-(4-METHOXY-PHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLOROMETHYL-4-(4-METHOXY-PHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER(475042-38-7)
• EPA Substance Registry System: 6-CHLOROMETHYL-4-(4-METHOXY-PHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER(475042-38-7)

Safety Data

• Hazardous Substances Data: 475042-38-7(Hazardous Substances Data)

Upstream product

• 638-07-3 ethyl (2-chloroaceto)acetate 
• 123-11-5 4-methoxy-benzaldehyde 
• 57-13-6 urea 

Downstream Products

• 1609956-02-6 4-(4-methoxy-phenyl)-2-oxo-6-selenocyanatomethyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 

Relevant articles and documents

Substitutional effects on the reactivity and thermal stability of dihydropyrimidinones

One of the advantages of dihydropyrimidinones (DHPMs) is the molecular diversity that could be achieved through their synthesis from a three-component reaction by varying the starting reaction materials. Differences in substituted functional groups could lead to varying reactivities and thermal stability amongst the analogues. In this study, two different classes of DHPMs were synthesized and the effects of the various substituents on the DHPM ring were investigated. The compounds were structurally characterized using single-crystal X-ray diffractometry, 1H, 13C, COSY, HSQC and HMBC NMR techniques, FT-IR and High Resolution Mass Spectrometry (HRMS). N1 methylation of the DHPM was found to increase the thermal stability of the series of DHPMs investigated, which is an added advantage in thermal reactions. The nature of the alkyl substituent of the ester group at position 5 of the DHPM was also found to affect the ease of the nucleophilic substitution reaction during the functionalization of the DHPMs. A complementary DFT study aided in understanding the above results as well as to compare the general stability of the range of compounds.

Synthesis and evaluation of dihydropyrimidinone-derived selenoesters as multi-targeted directed compounds against Alzheimer's disease

This paper describes the synthesis and evaluation of new dihydropyrimidinone (DHPM)-derived selenoesters as potential multi-targeted agents for the treatment of Alzheimer's disease. A series of DHPM-derived selenoesters were obtained with high structural

Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease

In this paper we report the design, synthesis and evaluation of a series of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease. The compounds show excellent results as acetylcholinesterase inhibitors, being as active as the standard drug. All these compounds also show very good antioxidant activity through different mechanisms of action. the Partner Organisations 2014.

Synthesis of new polyfunctional 5,6,7,8-tetrahydroimidazo-[1,5-c]pyrimidin- 5-ones by the aza-wittig reaction followed by intramolecular cyclization and 1,3-prototropic shift

Ethyl 2-oxo-6-[(triphenyl-λ5-phosphanylidene)aminomethyl] -1,2,3,4-tetrahydropyrimidine-5-carboxylates reacted with organic isocyanates according to the aza-Wittig pattern, and the subsequent intramolecular ring closure and 1,3-H shift resulted