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475150-69-7

(2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • (2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide

    Cas No: 475150-69-7

  • USD $ 10.0-10.0 / Milligram

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  • 475150-69-7 Structure

  • Basic information

    1. Product Name: (2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide
    2. Synonyms: (2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide;BAN ORL 24;(2R)-1-Benzyl-N-(3-spiro[isobenzofuran-1(3H),4'-piperidin]-1'-ylpropyl)-2-pyrrolidinecarboxamide;BANORL24diHCl;BAN ORL 24HCL;BAN ORL 24diHC1-;(R)-N-(3-(3H-Spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-1-benzylpyrrolidine-2-carboxam
    3. CAS NO:475150-69-7
    4. Molecular Formula: C27H35N3O2.2HCl
    5. Molecular Weight:
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 475150-69-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.19
    6. Refractive Index: N/A
    7. Storage Temp.: Desiccate at RT
    8. Solubility: Soluble in DMSO
    9. CAS DataBase Reference: (2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: (2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide(475150-69-7)
    11. EPA Substance Registry System: (2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide(475150-69-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 475150-69-7(Hazardous Substances Data)

475150-69-7 Usage

Uses

BAN ORL 24 is a KOR-3 (NOP) antagonist.

Check Digit Verification of cas no

The CAS Registry Mumber 475150-69-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,5,1,5 and 0 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 475150-69:
(8*4)+(7*7)+(6*5)+(5*1)+(4*5)+(3*0)+(2*6)+(1*9)=157
157 % 10 = 7
So 475150-69-7 is a valid CAS Registry Number.

475150-69-7Downstream Products

475150-69-7Relevant articles and documents

Structure-activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4′-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide

Trapella, Claudio,Fischetti, Carmela,Pela', Michela,Lazzari, Ilaria,Guerrini, Remo,Calo', Girolamo,Rizzi, Anna,Camarda, Valeria,Lambert, David G.,McDonald, John,Regoli, Domenico,Salvadori, Severo

experimental part, p. 5080 - 5095 (2009/12/24)

Twelve derivatives of the nociceptin/orphanin FQ (N/OFQ) receptor (NOP) antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4′-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide (Comp 24) were synthesized and tested in binding experiments performed on CHOsu

Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity

Goto, Yasuhiro,Arai-Otsuki, Sachie,Tachibana, Yukari,Ichikawa, Daisuke,Ozaki, Satoshi,Takahashi, Hiroyuki,Iwasawa, Yoshikazu,Okamoto, Osamu,Okuda, Shoki,Ohta, Hisashi,Sagara, Takeshi

, p. 847 - 849 (2007/10/03)

A focused library approach identifying novel leads to develop a potent ORL1 antagonist is described. Beginning from a compound identified by random screening, an exploratory library that exhibited a diverse display of pharmacophores was designed. After evaluating ORL1 antagonistic activity, a highly focused library was designed based on 3D-pharmacophore similarity to known actives. A novel D-proline amide class was identified in this library and was found to possess potent ORL1 antagonistic activity.

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