475174-68-6

Basic information

• Product Name: Pyrazolo[1,5-a]pyridine, 7-bromo-2-ethyl- (9CI)
• Synonyms: Pyrazolo[1,5-a]pyridine, 7-bromo-2-ethyl- (9CI)
• CAS NO: 475174-68-6
• Molecular Formula: C₉H₉BrN₂
• Molecular Weight: 225.08516
• Product Categories: ETHYL
• Mol File: 475174-68-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrazolo[1,5-a]pyridine, 7-bromo-2-ethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazolo[1,5-a]pyridine, 7-bromo-2-ethyl- (9CI)(475174-68-6)
• EPA Substance Registry System: Pyrazolo[1,5-a]pyridine, 7-bromo-2-ethyl- (9CI)(475174-68-6)

Safety Data

• Hazardous Substances Data: 475174-68-6(Hazardous Substances Data)

Upstream product

• 475174-65-3 2-ethylpyrazolo[1,5-a]pyridine 
• 475174-64-2 1-(but-1-yn-1-yl)pyridine 
• 475174-67-5 N-amino-2-(1-butynyl)pyridinium mesitylenesulfonate 
• 109-04-6 2-bromo-pyridine 

Downstream Products

• 475174-69-7 7-(2,4-dichlorophenyl)-2-ethylpyrazolo[1,5-a]pyridine 
• 475174-92-6 N-cyclopropylmethyl-N-[2-ethyl-7-(2-methoxy-4,6-dimethylphenyl)pyrazolo[1,5-a]pyridin-3-yl]amine 
• 475171-43-8 N,N-bis(cyclopropylmethyl)-2-ethyl-7-(4-methoxy-2-methylphenyl)pyrazolo[1,5-a]pyridin-3-amine 
• 475171-50-7 N,N-bis(cyclopropylmethyl)-2-ethyl-7-(2-methoxy-4-methylphenyl)pyrazolo[1,5-a]pyridin-3-amine 
• 475171-41-6 N,N-bis(cyclopropylmethyl)-2-ethyl-7-(2-methoxy-4,6-dimethylphenyl)pyrazolo[1,5-a]pyridin-3-amine 
• 475171-45-0 N,N-bis(cyclopropylmethyl)-2-ethyl-7-(4-methoxy-2,6-dimethylphenyl)pyrazolo[1,5-a]pyridin-3-amine 
• 475171-36-9 7-(2-chloro-4-methoxyphenyl)-2-ethyl-N,N-dipropylpyrazolo[1,5-a]pyridin-3-amine 
• 475171-40-5 2-ethyl-7-(4-methoxy-2-methylphenyl)-N,N-dipropylpyrazolo[1,5-a]pyridin-3-amine 
• 475171-67-6 N-(cyclopropylmethyl)-2-ethyl-7-(2-methoxy-4,6-dimethylphenyl)-N-(2-methoxyethyl)pyrazolo[1,5-a]pyridin-3-amine 
• 475171-68-7 N-(cyclopropylmethyl)-2-ethyl-N-(3-fluoropropyl)-7-(2-methoxy-4,6-dimethylphenyl)pyrazolo[1,5-a]pyridin-3-amine 
• 475171-70-1 N-(cyclopropylmethyl)-2-ethyl-7-(2-methoxy-4,6-dimethylphenyl)-N-[(tetrahydrofuran-3-yl)methyl]pyrazolo[1,5-a]pyridin-3-amine 
• 685885-75-0 N-(cyclopropylmethyl)-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]pyrazolo[1,5-a]pyridin-3-amine 
• 1380434-44-5 tert-butyl [2-ethyl-7-(2-methoxy-4,6-dimethylphenyl)-pyrazolo[1,5-a]pyridin-3-yl]carbamate 

Relevant articles and documents

Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: Potent and orally active antagonists of corticotropin-releasing factor 1 receptor

Design, synthesis, and structure-activity relationships of a series of 3-dialkylamino-7-phenyl pyrazolo[1,5-a]pyridines (I) as selective antagonists of the corticotropin-releasing factor 1 (CRF1) receptor are described. The most prominent compound to emerge from this work, 46 (E2508), exhibits potent in vitro activity, excellent drug-like properties, and robust oral efficacy in animal models of stress-related disorders. It has advanced into clinical trials.

7-phenylpyrazolopyridine compounds

A compound represented by the formula: [wherein R1 is methoxy, methylthio, ethyl, etc.; R5 and R6 are each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R40, R41 and R42 are C1-6 alkoxy while the remaining one is methoxymethyl, etc.], a salt thereof, or a hydrate of the foregoing. This compound has excellent antagonism against corticotropin-releasing factor receptor.

PYRAZOLO 1,5-A]PYRIDINES AND MEDICINES CONTAINING THE SAME

Compounds represented by the general formula: [wherein R1 represents methoxy, ethyl, methylthio, etc., R2, R3 and R4 each represent hydrogen, a halogen, etc., R5 and R6 each represent -X5-X6-X7 (wherein X5 represents a single bond or -CO-, X6 represents a single bond, -NR3a, etc. and X7 and R3a each represent hydrogen, C1-10 alkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.