476014-76-3

Basic information

• Product Name: 4-hydroxy-2-Piperidinone
• Synonyms: 4-hydroxy-2-Piperidinone;4-Hydroxy-piperidin-2-one;2-Piperidinone, 4-hydroxy-;4-hydroxy-2-Piperidi
• CAS NO: 476014-76-3
• Molecular Formula: C₅H₉NO₂
• Molecular Weight: 115.13046
• Mol File: 476014-76-3.mol

Chemical Properties

• Boiling Point: 352.3 °C at 760 mmHg
• Flash Point: 166.8 °C
• Appearance: /
• Density: 1.199 g/cm³
• Vapor Pressure: 2.28E-06mmHg at 25°C
• Refractive Index: 1.497
• Storage Temp.: 2-8°C
• Solubility: Methanol (Slightly, Sonicated)
• PKA: 14.01±0.20(Predicted)
• CAS DataBase Reference: 4-hydroxy-2-Piperidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-2-Piperidinone(476014-76-3)
• EPA Substance Registry System: 4-hydroxy-2-Piperidinone(476014-76-3)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39
• Hazardous Substances Data: 476014-76-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Hydroxy-2-Piperidinone is used as a synthetic intermediate for the production of various pharmaceutical goods. Its unique chemical structure allows it to be a key component in the synthesis of drugs with diverse therapeutic applications, including central nervous system agents, antibiotics, and other medicinal compounds.

InChI:InChI=1/C5H9NO2/c7-4-1-2-6-5(8)3-4/h4,7H,1-3H2,(H,6,8)

Upstream product

• 50607-30-2 piperidine-2,4-dione 
• 147028-51-1 4-cyano-3-hydroxybutanoic acid 
• 158849-52-6 4-cyano-3-hydroxybutyric acid methyl ester 

Downstream Products

• 50607-30-2 piperidine-2,4-dione 
• 476014-79-6 4-(tert-butyldiphenylsilyloxy)-2-ethoxypiperidine-1-carboxylic acid methyl ester 
• 476014-78-5 4-(tert-butyldiphenylsilyloxy)-2-oxopiperidine-1-carboxylic acid methyl ester 
• 476014-77-4 (±)-4-((tert-butyldiphenylsilyl)oxy)piperidin-2-one 
• 476014-80-9 4-hydroxy-6-methoxypiperidin-2-one 

Relevant articles and documents

OXAZOLIDONE COMPOUND, PREPARING METHOD AND APPLICATION THEREOF

The present invention relates to the field of a pharmaceutical compound, and more specifically, relates to a new oxazolidone compound, an enantiomer, a diastereoisomer and a raceme thereof, and a mixture thereof, and a pharmaceutically acceptable salt thereof, a preparation method thereof, an application thereof as a bioactive substance in a drug. The compound in the present invention has strong anticoagulant activity, does not affect the activity of thrombin, and can reduce the risk of hemorrhage. A pharmacokinetics experiment shows that the compound in the present invention further has good metabolic characteristics, and has a far better oral bioavailability than a positive contrastive agent rivaroxaban.

SUBSTITUTED CYCLIC COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted cyclic compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

A stereodivergent approach to substituted 4-hydroxypiperidines

A stereodivergent route toward both diastereomeric forms of functionalized 4-hydroxypiperidines has been successfully developed. This route involves biocatalytic generation of the enantiopure starting materials followed by functionalization via N-acyliminium ion-mediated CC-bond formation.