477251-98-2

Basic information

• Product Name: 5-(Methylthio)pyridine-3-boronic acid
• Synonyms: 5-(METHYLTHIO)PYRIDINE-3-BORONIC ACID;5-METHYLTHIO-3-PYRIDINEBORONIC ACID;5-(Methylthio)pyridine-3-boronic acid 96%;(5-(Methylthio)pyridin-3-yl)boronic acid;5-(Methylsulphanyl)pyridine-3-boronicacid
• CAS NO: 477251-98-2
• Molecular Formula: C₆H₈BNO₂S
• Molecular Weight: 169.01
• Product Categories: blocks;BoronicAcids;Pyridines
• Mol File: 477251-98-2.mol

Chemical Properties

• Melting Point: 210-213
• Boiling Point: 378.1°C at 760mmHg
• Flash Point: 182.4°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: 2-8°C
• PKA: 3.48±0.10(Predicted)
• CAS DataBase Reference: 5-(Methylthio)pyridine-3-boronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(Methylthio)pyridine-3-boronic acid(477251-98-2)
• EPA Substance Registry System: 5-(Methylthio)pyridine-3-boronic acid(477251-98-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 477251-98-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
5-(Methylthio)pyridine-3-boronic acid is used as a reagent in the Suzuki-Miyaura cross-coupling reaction, a method pivotal for the formation of carbon-carbon bonds. This reaction is widely employed in the synthesis of complex organic molecules, including those with potential pharmaceutical applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-(Methylthio)pyridine-3-boronic acid serves as a key building block for the synthesis of biologically active compounds. Its unique structure allows for the creation of a variety of pharmaceuticals, agrochemicals, and other fine chemicals, contributing to the development of new drugs and treatments.
Used in the Preparation of Pharmaceuticals:
5-(Methylthio)pyridine-3-boronic acid is utilized as a valuable intermediate in the preparation of pharmaceuticals. Its incorporation into drug molecules can enhance their therapeutic properties, making it an essential component in the advancement of medicinal chemistry.
Used in the Synthesis of Agrochemicals:
5-(Methylthio)pyridine-3-boronic acid also finds application in the synthesis of agrochemicals, where it can be used to create compounds with pesticidal or herbicidal properties, thereby contributing to agricultural productivity and crop protection.

InChI:InChI=1/C6H8BNO2S/c1-11-6-2-5(7(9)10)3-8-4-6/h2-4,9-10H,1H3

Upstream product

• 625-92-3 3,5-dibromopyridine 
• 624-92-0 Dimethyldisulphide 

Downstream Products

• 1298100-73-8 2-(S)-{[4-(4-methoxy-phenoxy)-2-(5-methylsulfanyl-pyridin-3-yl)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

8-(BIARYL) QUINOLINE PDE4 INHIBITORS

8-(biaryl) quinolines wherein the bi-aryl group at the 8-position is in a meta relationship to the quinoline group, are PDE4 inhibitors useful in the treatment of asthma, chronic bronchitis, chronic obstructive pulmonary disease, eosinophilic granuloma, psoriasis and other benign or malignant proliferative skin diseases, endotoxic shock, laminitis in horses, colic in horses, septic shock, ulcerative colitis, Crohn's disease, reperfusion injury of the myocardium and brain, inflammatory arthritis, chronic glomerulonephritis, atopic dermatitis, urticaria, adult respiratory distress syndrome, chronic obstructive pulmonary disease in animals, diabetes insipidus, allergic rhinitis, allergic conjunctivitis, vernal conjunctivitis, arterial restenosis, ortherosclerosis, atherosclerosis, neurogenic inflammation, pain, cough, rheumatoid arthritis, ankylosing spondylitis, transplant rejection, graft versus host disease, hypersecretion of gastric acid, bacterial, fungal induced sepsis, viral induced sepsis, fungal induced septic shock, viral induced septic shock, inflammation-mediated chronic tissue degeneration, cytokine-mediated chronic tissue degeneration, osteoarthritis, cancer, cachexia, muscle wasting, depression, memory impairment, tumour growth, or cancerous invasion of normal tissues.In another aspect, the present invention is directed to a method of enhancing cognition in a healthy subject comprising administering a safe cognition enhancing amount of phosphodiesterase-4 inhibitor. In particular, this invention is directed to a method of enhancing memory, learning, retention, recall, awareness and judgement in health subjects comprising administering a safe and cognition enhancing amount of a phosphodiesterase-4 inhibitor.