- Thermolysis of dimethyl Cis- and Trans-1 pthalimidoaziridine-2,3- dicarboxylates in the presence of dipolarophiles
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Thermolysis of dimethyl esters of stereoisomeric phthalimidoaziridine-2,3- dicarboxylic acids in the presence of dimethyl fumarate, dimethyl maleate, and N-phenylmaleimide occurred stereo-specifically and stereoselectively led to the formation of derivati
- Kuznetsov,Ushkov,Selivanov,Pan'Kova,Linden
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experimental part
p. 1200 - 1207
(2009/12/07)
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- Triflic anhydride-mediated synthesis of oxazoles
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N-Acyl amino acid esters undergo triflic anhydride-mediated cyclodehydration to form oxazoles and bisoxazoles in a simple one-pot transformation.
- Thalhammer, Armin,Mecinovi?, Jasmin,Schofield, Christopher J.
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supporting information; experimental part
p. 1045 - 1047
(2009/05/31)
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- PYRAZOLE DERIVATIVE
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A compound represented by Formula (I): wherein Ar1 represents Formula (II): Ar2 represents a 5- or 6-membered aromatic heterocyclic group which may be substituted; and X represents Formula (III): a salt thereof, or a solvate of the compound or the salt. A potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.
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Page/Page column 66
(2010/11/27)
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- HIV INTEGRASE INHIBITORS
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Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula (I) are inhibitors of HIV integrase and inhibitors of HIV replication wherein X1, X2, R4 and R5 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
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Page/Page column 26
(2008/06/13)
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