477870-14-7

Usage

Uses

Used in Pharmaceutical Industry:
2-Oxazolecarboxylic acid, 5-methoxy-, methyl ester (9CI) is used as a building block for the synthesis of novel pharmaceutical compounds. The presence of the oxazole ring and the 5-methoxy group enhances its potential for creating diverse drug candidates with improved biological activities and selectivity.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-Oxazolecarboxylic acid, 5-methoxy-, methyl ester (9CI) serves as a key intermediate for the development of new drugs. Its unique structural features allow researchers to explore its potential in designing molecules with enhanced pharmacological properties, such as improved potency, selectivity, and reduced side effects.
Used in Drug Design and Optimization:
2-Oxazolecarboxylicacid,5-methoxy-,methylester(9CI) is utilized in drug design and optimization processes to create new molecules with potential therapeutic applications. Its oxazole ring and 5-methoxy group can be further modified or functionalized to generate a wide range of bioactive molecules, targeting various diseases and conditions.

Upstream product

• 1191037-76-9 dimethyl cis-1-phthalimidoaziridine-2,3-dicarboxylate 
• 624-49-7 dimethylfumarate 
• 89464-63-1 dimethyloxalylglycine 

Downstream Products

• 865300-20-5 methyl 6-(4-fluorobenzyl)-4-hydroxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carboxylate 
• 439109-82-7 5-methoxyoxazole-2-carboxylic acid 

Relevant academic research and scientific papers

Thermolysis of dimethyl Cis- and Trans-1 pthalimidoaziridine-2,3- dicarboxylates in the presence of dipolarophiles

Thermolysis of dimethyl esters of stereoisomeric phthalimidoaziridine-2,3- dicarboxylic acids in the presence of dimethyl fumarate, dimethyl maleate, and N-phenylmaleimide occurred stereo-specifically and stereoselectively led to the formation of derivati

Triflic anhydride-mediated synthesis of oxazoles

N-Acyl amino acid esters undergo triflic anhydride-mediated cyclodehydration to form oxazoles and bisoxazoles in a simple one-pot transformation.

PYRAZOLE DERIVATIVE

A compound represented by Formula (I): wherein Ar1 represents Formula (II): Ar2 represents a 5- or 6-membered aromatic heterocyclic group which may be substituted; and X represents Formula (III): a salt thereof, or a solvate of the compound or the salt. A potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.

HIV INTEGRASE INHIBITORS

Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula (I) are inhibitors of HIV integrase and inhibitors of HIV replication wherein X1, X2, R4 and R5 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.