477889-77-3

Basic information

• Product Name: ETHYL 2-(1,3-BENZOTHIAZOL-2-YLSULFONYL)-2,2-DIFLUOROACETATE
• Synonyms: ETHYL 2-(1,3-BENZOTHIAZOL-2-YLSULFONYL)-2,2-DIFLUOROACETATE;(Benzothiazole-2-sulfonyl)-difluoro-acetic acid ethyl ester
• CAS NO: 477889-77-3
• Molecular Formula: C11H9F2NO4S2
• Molecular Weight: 321.32
• Mol File: 477889-77-3.mol

Chemical Properties

• Melting Point: 73-75 °C
• Boiling Point: 421.8±55.0 °C(Predicted)
• Appearance: /
• Density: 1.515±0.06 g/cm3(Predicted)
• PKA: -3.84±0.10(Predicted)
• CAS DataBase Reference: ETHYL 2-(1,3-BENZOTHIAZOL-2-YLSULFONYL)-2,2-DIFLUOROACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-(1,3-BENZOTHIAZOL-2-YLSULFONYL)-2,2-DIFLUOROACETATE(477889-77-3)
• EPA Substance Registry System: ETHYL 2-(1,3-BENZOTHIAZOL-2-YLSULFONYL)-2,2-DIFLUOROACETATE(477889-77-3)

Safety Data

• Hazardous Substances Data: 477889-77-3(Hazardous Substances Data)

Upstream product

• 149-30-4 2-Mercaptobenzothiazole 
• 910803-66-6 ethyl α-(1,3-benzothiazol-2-ylsulfonyl)-α-fluoroacetate 

Downstream Products

• 186204-66-0 2-(difluoromethanesulfonyl)-1,3-benzothiazole 

Relevant articles and documents

Modified Julia olefination on sugar-derived lactones: Synthesis of difluoro exo-glycals

We report the preparation of difluoro-exo-glycals by gem-difluoroolefination of benzylated sugar-derived lactones using a modified Julia reaction. The addition is highly stereo-selective, and the Smiles-rearrangement-elimination sequence can be carried out under microwave irradiation.

Scope and limitations of the Julia-Kocienski reaction with fluorinated sulfonylesters

The study of the Julia-Kocienski reaction between fluorinated arylsulfone and ketones is described. The corresponding fluoroalkenes were isolated in moderate to good yields from β- and δ-substituted cyclic ketones. From acyclic ketones and α-substituted c