186204-66-0

Basic information

• Product Name: 2-(difluoromethanesulfonyl)-1,3-benzothiazole
• Synonyms: 2-(difluoromethanesulfonyl)-1,3-benzothiazole
• CAS NO: 186204-66-0
• Molecular Weight: 249.262
• Mol File: 186204-66-0.mol
• Article Data: 13

Chemical Properties

• Melting Point: 133-135 °C
• Boiling Point: 348.4±52.0 °C(Predicted)
• Density: 1.564±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(difluoromethanesulfonyl)-1,3-benzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(difluoromethanesulfonyl)-1,3-benzothiazole(186204-66-0)
• EPA Substance Registry System: 2-(difluoromethanesulfonyl)-1,3-benzothiazole(186204-66-0)

Safety Data

• Hazardous Substances Data: 186204-66-0(Hazardous Substances Data)

Usage

General Description

2-(difluoromethanesulfonyl)-1,3-benzothiazole is a chemical compound with the molecular formula C8H5F2NO2S. It is an organofluorine compound that contains a benzothiazole ring and a sulfonyl fluoride functional group. 2-(difluoromethanesulfonyl)-1,3-benzothiazole has been studied for its potential use in organic synthesis and pharmaceutical research. It is a colorless to pale yellow solid that is soluble in organic solvents. Due to its unique structure and reactivity, 2-(difluoromethanesulfonyl)-1,3-benzothiazole has the potential to be used as a building block in the synthesis of various biologically active compounds and materials. Additionally, it possesses interesting properties that make it a valuable addition to the field of medicinal chemistry and drug development.

Upstream product

• 910803-66-6 ethyl α-(1,3-benzothiazol-2-ylsulfonyl)-α-fluoroacetate 
• 477889-77-3 ethyl 2-(benzo[d]thiazol-2-ylsulfonyl)-2,2-difluoroacetate 
• 943-08-8 2-[(difluoromethyl)sulfanyl]-1,3-benzothiazole 
• 75-45-6 Chlorodifluoromethane 
• 149-30-4 2-Mercaptobenzothiazole 
• 2492-26-4 sodium 2-mercaptobenzothiazole 
• 1241899-81-9 2-(benzo[d]thiazol-2-ylsulfonyl)-1-(4-bromophenyl)-2,2-difluoroethanone 

Downstream Products

• 1286740-21-3 C₁₇H₁₅F₂NO₂S₂ 
• 152878-34-7 2,6-anhydro-1-deoxy-1,1-difluoro-3,4,5,7-tetrakis-O-benzyl-D-gluco-hept-1-enitol 

Relevant articles and documents

Late-Stage 18F-Difluoromethyl Labeling of N-Heteroaromatics with High Molar Activity for PET Imaging

Despite a growing interest in CHF2 in medicinal chemistry, there is a lack of efficient methods for the insertion of CHF18F into druglike compounds. Herein described is a photoredox flow reaction for 18F-difluoromethylation of N-heteroaromatics that are widely used in medicinal chemistry. Following the two-step synthesis for a new 18F-difluoromethylation reagent, the photoredox reaction is completed within two minutes and proceeds by C?H activation, circumventing the need for pre-functionalization of the substrate. The method is operationally simple and affords straightforward access to radiolabeled N-heteroaromatics with high molar activity suitable for biological in vivo studies and clinical application.

Electrochemical reduction of fluoroalkyl sulfones for radical fluoroalkylation of alkenes

Radical fluoroalkylation of alkenes has been developed by electrochemical reduction of fluoroalkyl sulfones. A series of electron-deficient alkenes readily undergo hydrofluoroalkylation in good to excellent yields. This chemistry represents the first example of electrochemical generation of fluoroalkyl radicals from sulfones, which are used for practical radical fluoroalkylation of organic compounds.

CF2-containing 2-oxazoline ketone compounds and preparation method thereof

The invention provides a method for mildly and efficiently compounding a series of CF2-containing 2-oxazoline ketone compounds under a photocatalysis condition by actively combining difluoroalkylationreaction with carbon dioxide. The method provided by th