478260-43-4

Basic information

• Product Name: PHENYL(THIENO[2,3-B]QUINOLIN-2-YL)METHANONE
• Synonyms: PHENYL(THIENO[2,3-B]QUINOLIN-2-YL)METHANONE;2-benzoylthieno[2,3-b]quinoline
• CAS NO: 478260-43-4
• Molecular Formula: C18H11NOS
• Molecular Weight: 289.35
• Mol File: 478260-43-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PHENYL(THIENO[2,3-B]QUINOLIN-2-YL)METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: PHENYL(THIENO[2,3-B]QUINOLIN-2-YL)METHANONE(478260-43-4)
• EPA Substance Registry System: PHENYL(THIENO[2,3-B]QUINOLIN-2-YL)METHANONE(478260-43-4)

Safety Data

• Hazardous Substances Data: 478260-43-4(Hazardous Substances Data)

Upstream product

• 125917-60-4 2-chloro-3-(hydroxymethyl)quinoline 
• 98-86-2 acetophenone 
• 5399-30-4 2-oxo-2-phenylethylthiocyanate 
• 51925-41-8 3-formyl-2-mercaptoquinoline 
• 73568-25-9 2-chloro-3-quinoline carboxaldehyde 
• 70-11-1 α-bromoacetophenone 

Relevant articles and documents

Synthesis of a new series of aryl(thieno[2,3-b]quinolin-2-yl)methanone and 2-(2-aroyl-2,3-dihydrothieno[2,3-b]quinolin-3-yl)-1-arylethanone derivatives via sequential multi-component reaction

Abstract: An efficient, mild, and convenient protocol for the synthesis of aryl(thieno[2,3-b]quinolin-2-yl)methanone and 2-(2-aroyl-2,3-dihydrothieno[2,3-b]quinolin-3-yl)-1-arylethanone derivatives from readily available starting materials via a sequential multi-component reaction has been developed. The products were obtained with excellent yield (85–95%) within short reaction times (25-30?min) in DMF at room temperature. The structures of all synthesized compounds were characterized using IR, 1H NMR, 13C NMR, and mass spectral data and elemental analysis.

Facile Synthesis of 2-Acylthieno[2,3- b]quinolines via Cu-TEMPO-Catalyzed Dehydrogenation, sp2-C-H Functionalization (Nucleophilic Thiolation by S8) of 2-Haloquinolinyl Ketones

An efficient, solvent-free synthesis of 2-acylthieno[2,3-b]quinolines is reported from 2-halo-quinolinyl ketones through Cu-TEMPO catalyzed dehydrogenation, sp2-C-H functionalization using elemental sulfur as thiol surrogate (sulfur source) and tetrabutylammonium acetate as an ionic reaction medium. The optimized reaction conditions give excellent product yields under mild reaction conditions with chemoselectivity and broad functional group tolerance. The synthetic importance of the synthesized molecules is showcased further by Friedl?nder annulation, reduction, and alkene functionalization reactions.