478946-80-4

Basic information

• Product Name: 4-BROMOMETHYL-2-CHLORO-6-METHOXY-PYRIDINE
• Synonyms: 4-BROMOMETHYL-2-CHLORO-6-METHOXY-PYRIDINE
• CAS NO: 478946-80-4
• Molecular Formula: C₇H₇BrClNO
• Molecular Weight: 236.49358
• Mol File: 478946-80-4.mol

Chemical Properties

• Melting Point: 51-51.5 °C
• Boiling Point: 286.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.596±0.06 g/cm3(Predicted)
• PKA: 0.41±0.10(Predicted)
• CAS DataBase Reference: 4-BROMOMETHYL-2-CHLORO-6-METHOXY-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOMETHYL-2-CHLORO-6-METHOXY-PYRIDINE(478946-80-4)
• EPA Substance Registry System: 4-BROMOMETHYL-2-CHLORO-6-METHOXY-PYRIDINE(478946-80-4)

Safety Data

• Hazardous Substances Data: 478946-80-4(Hazardous Substances Data)

Upstream product

• 603-35-0 triphenylphosphine 
• 193001-91-1 2-chloro-4-hydroxymethyl-6-methoxypyridine 
• 5398-44-7 2,6-dichloropyridine-4-carboxylic acid 
• 99-11-6 citrazinic acid 
• 15855-06-8 2-chloro-6-methoxy-isonicotinic acid 

Downstream Products

• 1610358-82-1 (rac)-ethyl {[(2-{[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl]amino}-6-methoxypyridin-4-yl)methyl](methyl)oxido-λ⁶-sulfanylidene}carbamate 
• 1610358-65-0 (rac)-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{6-methoxy-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine 
• 1610359-10-8 2,2,2-trifluoro-N-{[(2-{[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl]amino}-6-methoxypyridin-4-yl)methyl](methyl)-λ⁴-sulfanylidene}acetamide 
• 1610359-09-5 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{6-methoxy-4-[(methylsulfanyl)methyl]pyridin-2-yl}pyridin-2-amine 

Relevant articles and documents

Asymmetric Synthesis of (S)-(-)-Acromelobic Acid

(S)-(-)-Acromelobic acid (1) was synthesized in nine steps in enantiomerically pure form from citrazinic acid (4) in an overall yield of 21%. The key steps of this synthesis are the introduction of the amino function by the bis(lactim) ether method and the introduction of the acid function by Stille coupling. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

NOVEL INDOLE DERIVATES AS FABP-4 INHIBITORS

The present invention relates to novel compounds (I) wherein R0, R1, R2, R3, R4, R5, R6, R7, R8, A, B, n, X, and Y are as defined in the description and claims; and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament, which acts on the fatty acid binding protein FABP-4. The present invention relates to novel compounds (I) wherein R0, R1, R2, R3, R4, R5, R6, R7, R8, A, B, n, X, and Y are as defined in the description and claims; and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament, which acts on the fatty acid binding protein FABP-4.

Nonproteinogenic amino acids: An efficient asymmetric synthesis of (S)-(-)-acromelobic acid and (S)-(-)-acromelobinic acid

An efficient synthesis of (S)-(-)-acromelobic acid (1) and (S)-(-)-acromelobinic acid (2) is described via asymmetric hydrogenation protocol. Asymmetric hydrogenation of dehydroamino acid derivative 23 using (R,R)-[Rh(DIPAMP)(COD)]BF4 catalyst followed by removal of the protective groups afforded (S)-(-)-acromelobic acid (1) in >98% ee. The key intermediate 23 was prepared from citrazinic acid (8). The dehydroamino acid derivative 33 required for the synthesis of (S)-(-)-2 was prepared from 2,5-lutidine (27), which upon hydrogenation using (S,S)-[Rh(Et-DuPHOS)(COD)]BF4 catalyst afforded (S)-(+)-34 in 93% yield and >96% ee. Removal of protective groups in (S)-(+)-34 afforded (S)-(-)-acromelobinic acid (2) in good overall yield.