99-11-6

Usage

Uses

Used in Chemical Synthesis:
Citrazinic acid is used as a key intermediate for the preparation of 2,6-dibromo-4-(hexoxymethyl)pyridine. It is also used to synthesize the derivatives of oxazinones and pyrimidinones.
Used in Pharmaceutical Industry:
Citrazinic acid is used as a building block for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be used in the development of new drugs and drug candidates.
Used in Research and Development:
Citrazinic acid is used in research and development for the study of its chemical properties and potential applications. It is a valuable compound for researchers working in the fields of organic chemistry, medicinal chemistry, and drug discovery.

Purification Methods

The acid is normally a yellow powder with a greenish shade, but is white when ultra pure and turns blue on long standing. It is insoluble in H2O but slightly soluble in hot HCl and soluble in alkali or carbonate solutions. It is purified by precipitation from alkaline solutions with dilute HCl, and dried in a vacuum over P2O5. The ethyl ester has m 232o (evacuated tube) and a pKa of 4.81 in MeOCH2CH2OH [IR: Pitha Coll Czech Chem Comm 28 1408 1963]. [Beilstein 22/7 V 24.]

InChI:InChI=1/C6H5NO4/c8-4-1-3(6(10)11)2-5(9)7-4/h1-2H,(H,10,11)(H2,7,8,9)/p-1

Upstream product

• 725679-43-6 citric acid α,α'-diamide 
• 130839-31-5 citric acid α-amide 
• 597-59-1 citric acid triamide 
• 1587-20-8 trimethyl citrate 
• 5398-44-7 2,6-dichloropyridine-4-carboxylic acid 
• 57-13-6 urea 
• 77-92-9 citric acid 
• 55-22-1 pyridine-4-carboxylic acid 

Downstream Products

• 5398-44-7 2,6-dichloropyridine-4-carboxylic acid 
• 91013-21-7 ethyl 2-ethoxy-6-hydroxyisonicotinate 
• 98996-85-1 2,6-dihydroxy-isonicotinic acid-(2-methoxy-ethyl ester) 
• 91642-09-0 2,6-dihydroxy-isonicotinic acid cyclohexyl ester 
• 6973-55-3 2,6-dioxopiperidine-4-carboxylic acid 
• 2016-99-1 2,6-dibromoisonicotinic acid 
• 99-14-9 tricarallylic acid 
• 499-12-7 1 propene 1,2,3 tricarboxylic acid 
• 7664-41-7 ammonia 
• 22652-14-8 2,6-dichloro-4-(trichloromethyl)pyridine 
• 42521-08-4 2,6-dichloroisonicotinoyl chloride 
• 42521-09-5 methyl 2,6-dichloroisonicotinate 
• 119308-57-5 methyl 2,6-dibromoisonicotinate 
• 99970-62-4 2,6-dihydroxy-3-phenylazo-isonicotinic acid 

Relevant academic research and scientific papers

Synthesis method of citrazinic acid

The invention belongs to the technical field of compound preparation and particularly relates to a synthesis method of citrazinic acid. The method adopts a hydrothermal reaction method of citric acidand urea and particularly comprises the steps of dissolving citric acid and urea in deionized water, performing ultrasound dispersion and intensive mixing, performing a hydrothermal reaction under a certain temperature condition in a reaction kettle, performing high-speed centrifugation on reaction liquid at last, removing a supernate, and drying an obtained yellow precipitate, namely a citrazinicacid product with good color, high yield and high purity. The method is mild in reaction condition, and simple to operate; one-step sulfuric acid hydrolysis is required only, and the product is highin purity (greater than 96%) and productivity (70-85%).

PROCESS FOR PRODUCTION OF 2-HYDROXY-4-SUBSTITUTED PYRIDINES

A process for preparing a 2-hydroxy-4-substituted pyridine compound using a microbiological method, a novel microorganism, and a novel compound are provided. According to the process, a function of a microorganism or a product obtained therefrom is exerted on a 4-substituted pyridine of the general formula (1): wherein R is a methyl group, a carboxyl group, a carbamoyl group, a hydroxyiminomethyl group or a cyano group, to obtain the corresponding 2-hydroxy-4-substituted pyridine compound. The novel microorganisms are the Delftia species YGK-A649 (FERM BP-10389), Delftia species YGK-C217 (FERM BP-10388), or Acidovorax species YGK-A854 (FERM BP-10387) and the novel compound is a 2-hydroxy-4-pyridinaldoxime.