479198-74-8Relevant articles and documents
INHIBITORS OF HEAT SHOCK FACTORS AND USES THEREOF
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, (2018/04/13)
The present disclosure relates to a class of mammalian heat shock factor (HSF) inhibitors, to pharmaceutical compositions comprising these inhibitors as well as to methods for using the inhibitors. The inhibitors inhibit stress-induced expression from heat shock gene promoters. Furthermore, the inhibitors are cytotoxic to a variety of human cancer cells types.
BENZOXAZOLE DERIVATIVES
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Page/Page column 60, (2009/10/01)
It is intended to provide a benzoxazole derivative or a pharmaceutically acceptable salt or solvate thereof which is useful in the early diagnosis of a conformation disease; a composition or a kit containing the same for diagnosing a conformation disease; a medical composition for ttreating and/or preventing a conformation disease; and so on.
A short and highly stereoselective synthesis of α-(2-aminothiazolyl)-C-nucleosides
Navarre, Jean-Michel,Guianvarc'h, Dominique,Farese-Di Giorgio, Audrey,Condom, Roger,Benhida, Rachid
, p. 2199 - 2202 (2007/10/03)
A short route to novel α-(2-aminothiazolyl)-C-nucleosides has been developed. The key step was the high diastereoselective reduction of the hemiacetal intermediates using L-Selectride, which afforded the corresponding R-diols in quantitative yields. These diols were converted, after C4-C1 ring closure and protecting groups cleavage, to their corresponding free α-C-nucleosides.
Synthesis, incorporation into triplex-forming oligonucleotide, and binding properties of a novel 2'-deoxy-C-nucleoside featuring a 6-(thiazolyl-5)benzimidazole nucleobase.
Guianvarc'h, Dominique,Fourrey, Jean-Louis,Maurisse, Rosalie,Sun, Jian-Sheng,Benhida, Rachid
, p. 4209 - 4212 (2007/10/03)
[reaction: see text] 6-(Thiazolyl-5)benzimidazole (B(t)()) was designed as a novel nucleobase for the specific recognition of an inverted A.T base pair in a triple helix motif. It was successfully incorporated into an 18-mer triplex-forming oligonucleotid