Methylthiazol-2-ylcarbaMic acid tert-butyl ester

Base Information

• Chemical Name: Methylthiazol-2-ylcarbaMic acid tert-butyl ester
• CAS No.: 479198-74-8
• Molecular Formula: C9H14N2O2S
• Molecular Weight: 214.28466
• Hs Code.: 2934100090
• Mol file: 479198-74-8.mol

Synonyms:Methylthiazol-2-ylcarbaMic acid tert-butyl ester

Chemical Property of Methylthiazol-2-ylcarbaMic acid tert-butyl ester

Chemical Property:

• Boiling Point: 268.2±23.0 °C(Predicted)
• PKA: 3.68±0.10(Predicted)
• PSA: 70.67000
• Density: 1.192±0.06 g/cm3(Predicted)
• LogP: 2.51440

Purity/Quality:

99% ^*data from raw suppliers

tert-Butylmethyl(thiazol-2-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methylthiazol-2-ylcarbaMic acid tert-butyl ester

There total 2 articles about Methylthiazol-2-ylcarbaMic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 1,3-thiazole-2-yl-carbamate (170961-15-6) + methyl iodide (74-88-4) → 2-(N-tert-butoxycarbonyl-N-methyl-amino)-thiazole (479198-74-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(03)00159-X

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 2-(N-tert-butoxycarbonyl-N-methyl-amino)-thiazole (479198-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 100 percent / pyridine

2.1: NaH / dimethylformamide / 30 h

2.2: 95 percent / dimethylformamide / 12 h / 20 °C

With pyridine; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/ol026609h

Reference yield: 87.0%

2-(N-tert-butoxycarbonyl-N-methyl-amino)-thiazole (479198-74-8) → tert-butyl 5-bromothiazol-2-yl(methyl)carbamate (1314095-64-1)

Guidance literature:

With N-Bromosuccinimide; In tetrahydrofuran; at 5 - 20 ℃; for 2h;

upstream raw materials:

tert-butyl 1,3-thiazole-2-yl-carbamate

methyl iodide

di-tert-butyl dicarbonate

Downstream raw materials:

{5-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-thiazol-2-yl}-methyl-carbamic acid tert-butyl ester

[5-((R)-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-hydroxy-methyl)-thiazol-2-yl]-methyl-carbamic acid tert-butyl ester

tert-butyl 5-bromothiazol-2-yl(methyl)carbamate

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