479206-20-7

Basic information

• Product Name: 1H-Inden-4-ol, 1-amino-2,3-dihydro- (9CI)
• Synonyms: 1H-Inden-4-ol, 1-amino-2,3-dihydro- (9CI);1-AMINO-2,3-DIHYDRO-1H-INDEN-4-OL
• CAS NO: 479206-20-7
• Molecular Formula: C9H11NO
• Molecular Weight: 149.18974
• Product Categories: AMINEPRIMARY;ALCOHOL
• Mol File: 479206-20-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 1H-Inden-4-ol, 1-amino-2,3-dihydro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Inden-4-ol, 1-amino-2,3-dihydro- (9CI)(479206-20-7)
• EPA Substance Registry System: 1H-Inden-4-ol, 1-amino-2,3-dihydro- (9CI)(479206-20-7)

Safety Data

• Hazardous Substances Data: 479206-20-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1H-Inden-4-ol, 1-amino-2,3-dihydro(9CI) is used as a building block for the synthesis of pharmaceuticals due to its potential biological activities. It can be utilized in the development of heterocyclic compounds with pharmacological properties, contributing to the creation of new drugs with therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical field, 1H-Inden-4-ol, 1-amino-2,3-dihydro(9CI) is used as a precursor in the synthesis of agrochemicals. Its potential biological activities make it a valuable component in the development of pesticides, herbicides, and other agrochemical products that can enhance crop protection and yield.
Used in Organic Chemistry Research:
1H-Inden-4-ol, 1-amino-2,3-dihydro(9CI) is used as a research compound in organic chemistry. Its unique structure and functional groups allow scientists to explore new reactions and synthesis pathways, potentially leading to the discovery of novel organic compounds with various applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1H-Inden-4-ol, 1-amino-2,3-dihydro(9CI) is used for the development of new pharmaceutical agents. Its hydrophilic and basic properties, along with its potential biological activities, make it a promising candidate for the synthesis of compounds with therapeutic effects, furthering the advancement of medicine.

Upstream product

• 103441-70-9 4-hydroxy-indan-1-one oxime 
• 103441-70-9 4-hydroxy-indan-1-one oxime 
• 40731-98-4 4-hydroxy-2,3-dihydroindan-1-one 

Downstream Products

• 1201362-27-7 2-anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one 

Relevant articles and documents

5,7-DIHYDRO-6H-PYRROLO[2,3-D]PYRIMIDIN-6-ONE DERIVATIVES FOR MARK INHIBITION

Compounds of formula I: are potent and selective inhibitors of microtubule affinity regulating kinase (MARK), and hence find use in treatment of Alzheimer's disease and other conditions associated with hyperphosphorylation of tau.

Hydroxy-1-aminoindans and derivatives: Preparation, stability, and reactivity

The chemical stability and reactivity of hydroxy-1-aminoindans and their N-propargyl derivatives are strongly affected by the position of the OH group and its orientation relative to that of the amino moiety. Thus, the 4- and 6-OH regioisomers were found to be stable, while the 5-OH analogues were found to be inherently unstable as the free bases. The latter, having a para orientation between the OH and the amino moieties, could be isolated only as their hydrochloride salts. 7-Hydroxy-1-aminoindans and 7-hydroxy-1- propargylaminoindans represent an intermediate case; while sufficiently stable even as free bases, they exhibit, under certain experimental conditions, unexpected reactivity. The instability of the 5- and 7-hydroxy-aminoindans is attributed to their facile conversion to the corresponding, reactive quinone methide (QM) intermediates. The o-QM obtained from 7-hydroxy-aminoindans was successfully trapped with ethyl vinyl ether via a Diels-Alder reaction to give tricyclic acetals 32a,b.

Novel Cerebroprotective Agents with Central Nervous System Stimulating Activity. 1. Synthesis and Pharmacology of 1-Amino-7-hydroxyindan Derivatives

To developed a novel cerebroprotective agent with central nervous system (CNS) stimulating activity, a series of 1-amino-7-hydroxyindan derivatives was synthesized, and their effects on the survival time of mice under hypoxic conditions were tested.CNS-stimulating activity was also evaluated by examining the promotional effect on the recovery from cerebral concussion induced coma in mice.Several compounds prolonged the survival time of mice in hypoxic conditions at a dose of 30 mg/kg (sc or ip) and 100 mg/kg (po).They also exhibited the promotional effects on recovery from coma at a dose of 100 mg/kg po.The three most potent compounds in both tests, 1-amino-7-hydroxy-6-(1-methylpropyl)indan (20), 1-amino-7-hydroxy-4,6-dimethyl-2-phenylindan (30), and 1-amino-7-hydroxy,2,2,4,6-tetramethylindan (35) were selected for further investigations.Structure-activity relationships were also discussed.