479544-01-9Relevant articles and documents
A catalytic enantioselective route to cis- and trans-3,4,4,5-tetrasubstituted cyclohexanones; remarkable chiral catalyst control in sequential catalytic 1,4-additions to cyclohexadienones
Imbos, Rosalinde,Minnaard, Adriaan J,Feringa, Ben L
, p. 2485 - 2489 (2007/10/03)
Asymmetric copper-phosphoramidite catalysed conjugate addition of Et2Zn to easily accessible, nearly enantiomerically pure cyclohexenones 2 and 4 was performed. Depending on the enantiomer of the chiral phosphoramidite used, the cis- or trans-3,4,4,5-tetrasubstituted cyclohexanones 5 and 6 could be formed selectively. Surprisingly, there is no directing effect of the 5-ethyl- or 4-alkoxy-substituents and the stereochemical outcome is only governed by the configuration of the chiral ligand.
A catalytic route to acyclic chiral building blocks: Applications of the catalytic asymmetric conjugate addition of organozinc reagents to cyclic enones
Jagt, Richard B.C.,Imbos, Rosalinde,Naasz, Robert,Minnaard, Adriaan J.,Feringa, Ben L.
, p. 221 - 229 (2007/10/03)
Through the Cu-phosphoramidite-catalyzed asymmetric conjugate addition a number of chiral cyclic enones are available with high ee. Here we report the sequential conjugate addition to these enones as a route towards multisubstituted chiral cyclic ketones.