479551-35-4

Basic information

• Product Name: 2-(3,4,5-Trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridine
• Synonyms: 2-(3,4,5-Trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 2-(3,4,5-trimethoxyphenyl)-
• CAS NO: 479551-35-4
• Molecular Formula: C₁₆H₁₆N₂O₃
• Molecular Weight: 284.30984
• Mol File: 479551-35-4.mol

Chemical Properties

• Boiling Point: 459.7°C at 760 mmHg
• Flash Point: 164.7°C
• Appearance: /
• Density: 1.223g/cm³
• Vapor Pressure: 3.38E-08mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: 2-(3,4,5-Trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4,5-Trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridine(479551-35-4)
• EPA Substance Registry System: 2-(3,4,5-Trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridine(479551-35-4)

Safety Data

• Hazardous Substances Data: 479551-35-4(Hazardous Substances Data)

Usage

Chemical structure

A unique structure consisting of a pyrrolopyridine core with a trimethoxyphenyl group attached at the 2-position.

Type of compound

A heterocyclic compound.

Pharmaceutical applications

Has potential pharmaceutical applications and has been studied for its potential as a therapeutic agent for various diseases.

Biological activities

Has shown promising biological activities, including anticancer and antimicrobial properties.

Drug development potential

Being investigated for its potential use in drug development.

Importance in medicinal chemistry

The unique structure of 2-(3,4,5-trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridine makes it an interesting target for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C16H16N2O3/c1-19-13-8-11(9-14(20-2)15(13)21-3)12-7-10-5-4-6-17-16(10)18-12/h4-9H,1-3H3,(H,17,18)

Upstream product

• 108-99-6 3-Methylpyridine 
• 1885-35-4 3,4,5-trimethoxybenzonitrile 
• 13534-99-1 2-Amino-3-bromopyridine 
• 53560-33-1 3,4,5-trimethoxyphenylacetylene 
• 52200-48-3 3-bromo-2-chloropyridine 
• 54230-88-5 8-bromotetrazolo[1,5-a]pyridine 

Downstream Products

• 913175-08-3 C₁₆H₁₆N₂O₄ 
• 913168-12-4 (quinolin-3-yl)-[2-(3,4,5-trimethoxy-phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-amine 
• 913083-71-3 4-chloro-2-(3,4,5-trimethoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

Ir-Catalyzed Intramolecular Transannulation/C(sp2)-H Amination of 1,2,3,4-Tetrazoles by Electrocyclization

An efficient strategy for the intramolecular denitrogenative transannulation/C(sp2)-H amination of 1,2,3,4-tetrazoles bearing C8-substituted arenes, heteroarenes, and alkenes is described. The process involves the generation of the metal-nitrene intermediate from tetrazole by the combination of [CpIrCl2]2 and AgSbF6. It has been shown that the reaction proceeds via an unprecedented electrocyclization process. The method has been successfully applied for the synthesis of a diverse array of α-carbolines and 7-azaindoles.

Expedient copper-free one-pot alkynylation-cyclization sequence for the preparation of 2-substituted 7-azaindoles

Abstract 2-Substituted 7-azaindoles are rapidly and efficiently prepared in a one-pot copper-free alkynylation-cyclization sequence starting from 2-aminopyridyl halides and terminal alkynes. Most importantly the amino nitrogen atom neither requires activation nor protection throughout the sequence.

NOVEL AZA- HETEROCYCLES SERVING AS KINASE INHIBITORS

The invention relates to compounds of formula (I), to their production and to their use for producing a medicament for treating diseases, particularly tumors and/or diseases in whose origin or progression kinases are involved.