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4803-27-4

Anthramycin is a DNA-binding antitumor antibiotic that selectively targets GC-rich regions of DNA, a feature linked to certain oncogenes. Structurally, it belongs to the pyrrolo[1,4]benzodiazepine (PBD) class and contains an acrylamide side chain critical for its biological activity. Research has explored synthetic routes to optimize its production, including palladium-catalyzed coupling reactions for side-chain attachment, as well as novel derivatives like the oxazolo[2,3-c][1,4]benzodiazepine (OBD) system, which may enhance DNA recognition and therapeutic potential. These efforts aim to improve the compound's efficacy and synthetic accessibility for anticancer applications.

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  • 4803-27-4 Structure

  • Basic information

    1. Product Name: Anthramycin
    2. Synonyms: Anthramycin;Antramycin;(11R,11aS,βE)-5,10,11,11a-Tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo[2,1-c][1,4]benzodiazepin-2-acrylamide;(11R,11aS,βE)-5,10,11,11a-Tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine-2-acrylamide
    3. CAS NO:4803-27-4
    4. Molecular Formula: C16H17N3O4
    5. Molecular Weight: 315.327
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 4803-27-4.mol

  • Chemical Properties

    1. Melting Point: 191°C
    2. Boiling Point: 454.88°C (rough estimate)
    3. Flash Point: 365°C
    4. Appearance: /
    5. Density: 1.1817 (rough estimate)
    6. Vapor Pressure: 2.05E-19mmHg at 25°C
    7. Refractive Index: 1.6500 (estimate)
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: Anthramycin(CAS DataBase Reference)
    11. NIST Chemistry Reference: Anthramycin(4803-27-4)
    12. EPA Substance Registry System: Anthramycin(4803-27-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 4803-27-4(Hazardous Substances Data)

4803-27-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4803-27-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,0 and 3 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4803-27:
(6*4)+(5*8)+(4*0)+(3*3)+(2*2)+(1*7)=84
84 % 10 = 4
So 4803-27-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H17N3O4/c1-8-2-4-10-13(14(8)21)18-15(22)11-6-9(3-5-12(17)20)7-19(11)16(10)23/h2-5,7,11,15,18,21-22H,6H2,1H3,(H2,17,20)/b5-3+

4803-27-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Anthramycin

1.2 Other means of identification

Product number -
Other names (11R,11aS)-5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo<2,1-c><1,4>benzodiazepin-2-trans-acrylamid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4803-27-4 SDS

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