Synonyms:Anthramycin;Anthramycin, (11a alpha)-Isomer;Antramycin
99%, *data from raw suppliers
ANTHRAMYCIN 95.00% *data from reagent suppliers
There total 1 articles about Antramycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
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The research focuses on the synthesis and reactivity of a novel oxazolo[2,3-c][1,4]benzodiazepine (OBD) ring system, which has potential DNA recognition capabilities and could be a new class of anthramycins, a type of antitumor antibiotics. The purpose of the study was to create a compound that could selectively bind to GC-rich regions of DNA, which are associated with some oncogenes, and to compare its properties with the pyrrolo[2,1-c][1,4]benzodiazepine (PBD) system found in DNA-binding anthramycin antitumor antibiotics. The researchers synthesized the OBD ring system through a novel route involving the formation of oxazolidine (C)-ring and attachment of the A-ring fragment via N-benzoylation, followed by steps leading to ring closure.
The research focuses on the attachment of the anthramycin acrylamide side chain to the pyrrolo(1,4)benzodiazepine structure via a palladium-catalyzed coupling reaction of a vinyl triflate. Anthramycin, an antitumor antibiotic, has a complex synthesis process. The study explores a more efficient route by converting the 2-keto group in the pyrrolo ring to a vinyl triflate and then coupling it with various reagents. Key chemicals involved include N-methyl isatoic anhydride, L-hydroxyproline, triflic anhydride, pyridine, tributylvinylstannane, ethyl acrylate, and palladium catalysts such as (Ph3P)2Pd and PdCl2. The methodology provides a convenient procedure for constructing anthramycin derivatives, offering a rapid entry into the pyrrolo(1,4)benzodiazepine structure with the desired side chain.
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