481048-22-0Relevant articles and documents
ERP ((3R)-2,4-diiodo-3-N-methyl butylamine-1-ene) compound as well as preparation method and application thereof
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Paragraph 0043-0059, (2019/08/03)
The invention provides an ERP ((3R)-2,4-diiodo-3-N-methyl butylamine-1-ene) compound as well as a preparation method and an application thereof. Specifically, according to the provided method, tetrahydrofuran is taken as a reaction solvent, a reduced pressure distillation method is adopted for purification during aftertreatment, the reaction conversion efficiency is notably improved, and the reaction time is greatly shortened; a few reaction by-products are produced, aftertreatment is simple silica gel column purification is not required, and the method is more suitable for industrial production. According to the technical scheme, production of waste liquids and waste solids is reduced, and therefore, environmental pollution is reduced; on the other hand, operation steps are simplified, the production cycle is shortened, and the production cost is reduced.
(3R)-2-iodo-4-benzyloxy-3-methyl-1-ene compound as well as preparation method and application thereof
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Paragraph 0056; 0057; 0058, (2019/08/02)
The invention provides a (3R)-2-iodo-4-benzyloxy-3-methyl-1-ene compound as well as a preparation method and an application thereof, more particularly relates to a novel compound ERP-2 as well as a preparation method and an application thereof, also provi
FE/CU-MEDIATED KETONE SYNTHESIS
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, (2019/01/22)
Provided herein are methods for preparing ketone-containing organic molecules. The methods are based on novel iron/copper-mediated ("Fe/Cu-mediated") coupling reactions. The Fe/Cu-mediated coupling reaction can be used in the preparation of complex molecu
Method for preparing eribulin and intermediate thereof
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Paragraph 0047-0048, (2018/09/08)
The present invention relates to a method for preparing eribulin and an intermediate thereof. In particular, the invention relates to a method for preparing formula 1 compound, (3R)-2,4-dihalo-3-methylbut-1-ene. The invention also provides a method for preparing halichondrin and derivatives thereof such as the eribulin from the formula 1 compound.
A process for the preparation of the date breene intermediate and its preparation method (by machine translation)
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, (2018/11/03)
The invention relates to a method of preparing intermediates in the date breene. Specifically, the invention relates to a kind of formula III, formula IV or formula X compound of formula, wherein R1 Is alkyl, or a substituted or non-substituted
Fe/Cu-Mediated One-Pot Ketone Synthesis
Kumar, Vemula Praveen,Babu, Vaddela Sudheer,Yahata, Kenzo,Kishi, Yoshito
supporting information, p. 2766 - 2769 (2017/05/24)
An Fe/Cu-mediated one-pot ketone synthesis was reported. Unlike Ni- and Pd-mediated one-pot ketone syntheses, the reported Fe/Cu-mediated method allowed selective activation and coupling of alkyl iodides over vinyl iodides. The newly developed one-pot ket
PROCESS FOR PREPARATION OF (3R)-2,4-DI-LEAVING GROUP-3-METHYLBUT-1-ENE
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, (2013/06/27)
The specification relates to compounds and process for the preparation of a compound of formula 7, where LG is a leaving group and hal is a halide and is Cl, Br or I. The compound of formula 7 can be useful in the preparation of natural products, such as
New syntheses of E7389 C14-C35 and halichondrin C14-C38 building blocks: Double-inversion approach
Kim, Dae-Shik,Dong, Cheng-Guo,Kim, Joseph T.,Guo, Haibing,Huang, Jian,Tiseni, Paolo S.,Kishi, Yoshito
supporting information; scheme or table, p. 15636 - 15641 (2010/01/30)
With sequential use of catalytic asymmetric Cr-mediated coupling reactions, E7389 C14-C35 and halichondrin C14-C38 building blocks have been stereoselectively synthesized. The C19-C20 bond is first formed via the catalytic asymmetric Ni/Cr-mediated coupli
Asymmetric Ni(II)/Cr(II)-mediated coupling reaction: catalytic process.
Choi, Hyeong-Wook,Nakajima, Katsumasa,Demeke, Damtew,Kang, Fu-An,Jun, Hyuk-Sang,Wan, Zhao-Kui,Kishi, Yoshito
, p. 4435 - 4438 (2007/10/03)
[reaction: see text] The stable, crystalline Cr(III)/sulfonamide complex 1a is shown to be an effective catalyst for the Ni/Cr-mediated coupling reaction. A possible mechanism is suggested for the process. 1a is also effective for other Cr-mediated coupli