157322-47-9

Basic information

• Product Name: Eribulin intermediate
• Synonyms: Eribulin mesylate intermediate3;Eribulin intermediate ERB;3-((2S,5S)-5-((3R,5R)-3-hydroxy-6-iodo-5-methylhept-6-enyl)-4-methylenetetrahydrofuran-2-yl)propyl pivalate;[2S-[2alpha,5beta(3S*,5S*)]]-2,2-Dimethylpropanoic acid 3-[tetrahydro-5-(3-hydroxy-6-iodo-5-methyl-6-heptenyl)-4-methylene-2-furanyl]propyl ester
• CAS NO: 157322-47-9
• Molecular Formula: C₂₁H₃₅IO₄
• Molecular Weight: 478.4
• EINECS: -0
• Product Categories: Intermediates
• Mol File: 157322-47-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 491.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• PKA: 14.89±0.20(Predicted)
• CAS DataBase Reference: Eribulin intermediate(CAS DataBase Reference)
• NIST Chemistry Reference: Eribulin intermediate(157322-47-9)
• EPA Substance Registry System: Eribulin intermediate(157322-47-9)

Safety Data

• Hazardous Substances Data: 157322-47-9(Hazardous Substances Data)

Usage

Uses

[2S-[2α,5β(3S*,5S*)]]-2,2-Dimethyl-Propanoic Acid 3-[tetrahydro-5-(3-hydroxy-6-iodo-5-methyl-6-heptenyl)-4-methylene-2-furanyl]propyl Ester,can be used in the synthesis of norhalichondrin B.

Upstream product

• 1159006-38-8 (3R,5R)-1-((2S,5S)-5-(3-hydroxypropyl)-3-methylenetetrahydrofuran-2-yl)-6-iodo-5-methylhept-6-en-3-ol 
• 3282-30-2 pivaloyl chloride 
• 1191268-97-9 C₂₃H₂₉ClOSi 
• 481048-21-9 3-((2S,5S)-3-methylene-5-(3-(t-butyldiphenylsilyloxy)propyl)tetrahydrofuran-2-yl)propanol 
• 1039627-96-7 C₁₂H₂₁IO₃ 
• 30435-87-1 2,2-dimethylpropionic acid-4-oxo-butyl ester 
• 1193375-09-5 C₁₂H₂₀ClIO₂ 
• 1443455-05-7 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propyl pivalate 
• 481048-22-0 (3R)-2,4-diiodo-3-methylbut-1-ene 
• 481048-34-4 3-((2S,5S)-3-methylene-5-(3-(t-butyldiphenylsilyloxy)propyl)tetrahydrofuran-2-yl)propanal 

Downstream Products

• 253128-10-8 3-((2S,5S)-5-(2-((2S,4R,6R)-6-(((2S,3S,4R,5R)-5-((S)-2,3-bis((tert-butyldimethylsilyl)oxy)propyl)-4-methoxy-3-((phenylsulfonyl)methyl)tetrahydrofuran-2-yl)methyl)-4-methyl-5-methylenetetrahydro-2H-pyran-2-yl)ethyl)-4-methylenetetrahydrofuran-2-yl)propan-1-ol 
• 480444-16-4 3-((2S,5S)-5-(2-((2S,4R,6R)-6-(((2S,3S,4R,5R)-5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-4-methoxy-3-((phenylsulfonyl)methyl)tetrahydrofuran-2-yl)methyl)-4-methyl-5-methylenetetrahydro-2H-pyran-2-yl)ethyl)-4-methylenetetrahydrofuran-2-yl)propyl pivalate 

Relevant articles and documents

Preparation method of eribulin intermediate

The invention provides a preparation method of an eribulin intermediate. According to the preparation method, a brand-new route and an intermediate are adopted to prepare a key intermediate ERB, compared with the prior art, the reaction route is greatly simplified, the reaction yield and the selectivity of a new chiral center of a target product are remarkably improved; and the preparation methodis especially suitable for industrial application.

PROCESS FOR THE PREPARATION OF MACROCYCLIC KETONE ANALOGS OF HALICHONDRIN B

The present invention discloses a novel process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts thereof and to novel intermediates which are produced during the course of carrying out the novel process.

A Total synthesis of norhalichondrin B

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