157322-47-9

Usage

Uses

Used in Pharmaceutical Industry:
Eribulin intermediate is used as a key intermediate for the synthesis of norhalichondrin B, a potent anticancer agent. Its unique chemical structure allows for the development of innovative drugs that target cancer cells effectively, making it a valuable asset in the fight against various types of cancer.
Used in Anticancer Applications:
Eribulin intermediate is employed in the development of anticancer drugs, particularly those targeting solid malignancies. Its role in the synthesis of norhalichondrin B contributes to the modulation of oncological signaling pathways, leading to the inhibition of tumor growth and progression. Additionally, its potential synergistic effects when combined with conventional chemotherapeutic drugs can enhance chemo-sensitivity and efficacy in resistant cases.
Used in Drug Delivery Systems:
To improve the delivery, bioavailability, and therapeutic outcomes of drugs synthesized using Eribulin intermediate, novel drug delivery systems have been developed. These systems utilize various organic and metallic nanoparticles as carriers for the efficient delivery of the synthesized drugs, targeting cancer cells more effectively and enhancing the overall treatment process.

Upstream product

• 481048-21-9 3-((2S,5S)-3-methylene-5-(3-(t-butyldiphenylsilyloxy)propyl)tetrahydrofuran-2-yl)propanol 
• 1039627-96-7 C₁₂H₂₁IO₃ 
• 30435-87-1 2,2-dimethylpropionic acid-4-oxo-butyl ester 
• 1193375-09-5 C₁₂H₂₀ClIO₂ 
• 1443455-05-7 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propyl pivalate 
• 481048-22-0 (3R)-2,4-diiodo-3-methylbut-1-ene 
• 1191268-97-9 C₂₃H₂₉ClOSi 
• 481048-34-4 3-((2S,5S)-3-methylene-5-(3-(t-butyldiphenylsilyloxy)propyl)tetrahydrofuran-2-yl)propanal 
• 1139773-92-4 C₃₉H₆₃NO₅Si₂ 

Downstream Products

• 253128-10-8 3-((2S,5S)-5-(2-((2S,4R,6R)-6-(((2S,3S,4R,5R)-5-((S)-2,3-bis((tert-butyldimethylsilyl)oxy)propyl)-4-methoxy-3-((phenylsulfonyl)methyl)tetrahydrofuran-2-yl)methyl)-4-methyl-5-methylenetetrahydro-2H-pyran-2-yl)ethyl)-4-methylenetetrahydrofuran-2-yl)propan-1-ol 
• 480444-16-4 3-((2S,5S)-5-(2-((2S,4R,6R)-6-(((2S,3S,4R,5R)-5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-4-methoxy-3-((phenylsulfonyl)methyl)tetrahydrofuran-2-yl)methyl)-4-methyl-5-methylenetetrahydro-2H-pyran-2-yl)ethyl)-4-methylenetetrahydrofuran-2-yl)propyl pivalate 

Relevant academic research and scientific papers

Preparation method of eribulin intermediate

The invention provides a preparation method of an eribulin intermediate. According to the preparation method, a brand-new route and an intermediate are adopted to prepare a key intermediate ERB, compared with the prior art, the reaction route is greatly simplified, the reaction yield and the selectivity of a new chiral center of a target product are remarkably improved; and the preparation methodis especially suitable for industrial application.

Compounds and synthesis method for Eribulin-B synthesis

The invention relates to synthesis of an Eribulin intermediate, and concretely relates to compounds and a synthesis method for Eribulin-B synthesis. TBDS protection is changed into PV protection, so that the key intermediate Eibulin-B can be directly prepared without replacing a protecting group in three steps, the subsequent operation risk is reduced, and the yield is reduced.

PROCESS FOR THE PREPARATION OF MACROCYCLIC KETONE ANALOGS OF HALICHONDRIN B

The present invention discloses a novel process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts thereof and to novel intermediates which are produced during the course of carrying out the novel process.

PROCESS FOR PREPARATION OF ERIBULIN AND INTERMEDIATES THEREOF

The present application provides process for preparation of 4-Methylene tetrahydrofuran compound of formula II, which is useful as an intermediate for the preparation of halichondrin B analogues such as Eribulin.