492468-16-3 Usage
Uses
Used in Organic Synthesis:
Ethyl (1R,2S)-2-cyanocyclopropane-1-carboxylate is used as a reagent in various organic synthesis reactions for the preparation of cyclopropanes and other functionalized cyclopropane derivatives. Its unique structure and reactivity make it a valuable component in creating complex organic molecules.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, ethyl (1R,2S)-2-cyanocyclopropane-1-carboxylate is used as a building block in the synthesis of pharmaceuticals and other biologically active compounds. Its specific stereochemistry allows for the creation of enantiomerically pure compounds, which is essential for the development of effective and safe medications.
Used in Research and Development:
Ethyl (1R,2S)-2-cyanocyclopropane-1-carboxylate is also utilized in research and development settings, where its properties and reactivity are studied to explore new chemical reactions and applications. Its versatility and importance in organic chemistry make it a valuable tool for advancing scientific knowledge and innovation.
Check Digit Verification of cas no
The CAS Registry Mumber 492468-16-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,2,4,6 and 8 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 492468-16:
(8*4)+(7*9)+(6*2)+(5*4)+(4*6)+(3*8)+(2*1)+(1*6)=183
183 % 10 = 3
So 492468-16-3 is a valid CAS Registry Number.
492468-16-3Relevant articles and documents
Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins
Chen, Ying,Ruppel, Joshua V.,Zhang, X. Peter
, p. 12074 - 12075 (2008/03/27)
The cobalt(II) complex of a D2-symmetric chiral porphyrin [Co(1)] is an effective catalyst for asymmetric cyclopropanation of electron-deficient olefins, including α,β-unsaturated esters, amides, ketones, and nitriles. Due to the absence of dimerization of diazo compounds, the catalytic reactions can be performed in one-pot protocol using olefins as the limiting reagent, forming the desired electrophilic cyclopropane derivatives in high yields and selectivities under mild conditions. In most cases, both excellent diastereo- and enantioselectivity were achieved. Copyright
An efficient and highly enantio- and diastereoselective cyclopropanation of olefins catalyzed by Schiff-base ruthenium(II) complexes
Miller, Jason A.,Jin, Wiechang,Nguyen, Sonbinh T.
, p. 2953 - 2956 (2007/10/03)
Both electron-rich and electron-deficient olefins - such as styrene and methyl methacrylate - undergo efficient (yields > 90%) cyclopropanation with ethyl diazoacetate as the carbene source to give predominantly trans products with exceptionally high enantioselectivity when the (salen)Ru catalyst shown is used (see scheme).
