492468-97-0

Basic information

• Product Name: 8-Methoxy-5-iodo-[1,2,4]triazolo[1,5-a]pyridin-2-yl-amine
• Synonyms: 8-Methoxy-5-iodo-[1,2,4]triazolo[1,5-a]pyridin-2-yl-amine;5-Iodo-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-amine;5-Iodo-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
• CAS NO: 492468-97-0
• Molecular Formula: C₇H₇IN₄O
• Molecular Weight: 290.06115
• Mol File: 492468-97-0.mol

Chemical Properties

• Appearance: /
• Density: 2.25
• Refractive Index: 1.813
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 8-Methoxy-5-iodo-[1,2,4]triazolo[1,5-a]pyridin-2-yl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Methoxy-5-iodo-[1,2,4]triazolo[1,5-a]pyridin-2-yl-amine(492468-97-0)
• EPA Substance Registry System: 8-Methoxy-5-iodo-[1,2,4]triazolo[1,5-a]pyridin-2-yl-amine(492468-97-0)

Safety Data

• Hazardous Substances Data: 492468-97-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H7IN4O/c1-13-4-2-3-5(8)12-6(4)10-7(9)11-12/h2-3H,1H3,(H2,9,11)

Upstream product

• 10201-71-5 3-methoxypyridin-2-amine 
• 175965-65-8 8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine 
• 175965-58-9 ethyl N-[(3-methoxypyridin-2-yl)carbamothioyl]carbamate 

Downstream Products

• 634195-36-1 8-methoxy-5-(4-methoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine 
• 634195-42-9 8-methoxy-5-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine 
• 685135-78-8 8-methoxy-5-(4-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine 
• 685135-47-1 8-methoxy-5-o-tolyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine 
• 492468-98-1 8-methoxy-5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl-amine 

Relevant articles and documents

Lead generation: Sowing the seeds for future success

Lead generation and the associated hit-to-lead process are key strategic elements in modern pharmaceutical research, and most companies have implemented this concept. Efficient lead generation is one of the main attempts to reduce the high attrition rates observed along the drug discovery process by focussing on the early developmental phases. The level of integration of the lead generation activities within the discovery organization, the flexibility in assessing and implementing new chemistries and new technologies, the high-quality standards set for the identification of the best possible chemical lead series will ultimately determine the future success in discovering new medicines.

Synthetic access to 2-amido-5-aryl-8-methoxy-triazolopyridine and 2-amido-5-morpholino-8-methoxy-triazolopyridine derivatives as potential inhibitors of the adenosine receptor subtypes

Two versatile and complementary synthetic strategies towards 2-amido-5-aryl-8-methoxy-triazolopyridine derivatives and 2-amido-5-morpholino-8-methoxy-triazolopyridine derivatives in five steps are presented. The key step in each synthetic route can be constituted as the formation of the respective triazolopyridine derivative precursors in 78% and 57% yield, respectively, through an intermediately formed 4H-[1,2,4]oxadiazol-5-one. The final Suzuki coupling/amidation allowed the straightforward access to the desired triazolopyridine derivatives which have not been described previously. Notably, these triazolopyridine-scaffold bears three vectors of diversity which offer maximum flexibility in design and combinatorial synthesis of molecules with a potentially useful inhibitory activity towards adenosine receptor subtypes.

Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives

The invention is a compound of formula or a pharmaceutically acceptable salt thereof, wherein R1and R2are as defined in the specification. A compound of formula I has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor.