Electrochemical synthesis of 1,2,4-triazole-fused heterocycles
A reagent-free intramolecular dehydrogenative C-N cross-coupling reaction has been developed under mild electrolytic conditions. In this atom- and step-economical one-pot process, valuable 1,2,4-triazolo[4,3-a]pyridines and related heterocyclic compounds could be synthesized efficiently from commercially available aliphatic or (hetero)aromatic aldehydes and 2-hydrazinopyridines. Various functional groups are compatible with this metal- and oxidant-free protocol which can be carried out on a gram scale easily. This novel method was applied to the synthesis of one of the top-selling drugs Xanax and late stage functionalization for generating chemical diversity in biologically relevant lead molecules.
Ye, Zenghui,Ding, Mingruo,Wu, Yanqi,Li, Yong,Hua, Wenkai,Zhang, Fengzhi
supporting information
p. 1732 - 1737
(2018/04/30)
Synthesis method of 1,2,4-triazolohetercyclic compound
The invention provides a method for synthesizing a 1,2,4-triazolohetercyclic compound. The method comprises the following steps: dissolving a 2-hydrazinohetercyclic compound (I) and an aldehyde compound (II) into acetonitrile A; stirring at 25 DEG C to 80
-
Paragraph 0042; 0043
(2018/01/09)
RuCl3/Oxone: An efficient combination for the synthesis of 3-aryl-[1,2,4]triazolo[4,3-a]pyridines from 2-(2-arylidenehydrazinol)pyridines
An efficient and convenient method for the synthesis of 3-aryl[1,2,4]triazolo[4,3-a]pyridines has been developed involving RuCl3/Oxone oxidative cyclization of 2-(2-arylidenehydrazinyl)pyridines, which occurs chemoselectively at the pyridine ni
Swamy, Tallapally,Raviteja, Padma,Srikanth, Goskula,Reddy, Basi V. Subba,Ravinder, Vadde
supporting information
p. 5596 - 5598
(2016/11/28)
Synthesis of 1,2,4-Triazolo[4,3-a]pyridines and Related Heterocycles by Sequential Condensation and Iodine-Mediated Oxidative Cyclization
A facile and efficient approach to access 1,2,4-triazolo[4,3-a]pyridines and related heterocycles has been accomplished through condensation of readily available aryl hydrazines with corresponding aldehydes followed by iodine-mediated oxidative cyclizatio
I2-TBHP-catalyzed one-pot highly efficient synthesis of 4,3-fused 1,2,4-triazoles from: N -tosylhydrazones and aromatic N-heterocycles via intermolecular formal 1,3-dipolar cycloaddition
I2-TBHP-catalyzed azomethine imine generation and subsequent regioselective 1,3-dipolar cycloaddition (DC) with aromatic N-heterocycles was developed to afford various 4,3-fused 1,2,4-triazoles in excellent yields. The method is operationally simple and highly efficient with broad functional group tolerance.
Inturi, Surendra Babu,Kalita, Biswajit,Ahamed, A. Jafar
supporting information
p. 11061 - 11064
(2016/12/07)
A simple and efficient automatable one step synthesis of triazolopyridines from carboxylic acids
Triazolopyridines can be rapidly and efficiently synthesized from a variety of carboxylic acids with 2-hydrazinopyridines in one simple step. The use of commercially available PS-PPh3 resin combined with microwave heating delivered the product
Wang, Ying,Sarris, Kathy,Sauer, Daryl R.,Djuric, Stevan W.
p. 2237 - 2240
(2007/10/03)
More Articles about upstream products of 4926-15-2