4926-15-2

Basic information

• Product Name: 6-methyl-3-phenyl[1,2,4]triazolo[4,3-a]pyridine
• CAS NO: 4926-15-2
• Molecular Formula: C₁₃H₁₁N₃
• Molecular Weight: 209.2465
• Mol File: 4926-15-2.mol
• Article Data: 6

Chemical Properties

• Density: 1.19g/cm³
• Refractive Index: 1.657
• CAS DataBase Reference: 6-methyl-3-phenyl[1,2,4]triazolo[4,3-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-3-phenyl[1,2,4]triazolo[4,3-a]pyridine(4926-15-2)
• EPA Substance Registry System: 6-methyl-3-phenyl[1,2,4]triazolo[4,3-a]pyridine(4926-15-2)

Safety Data

• Hazardous Substances Data: 4926-15-2(Hazardous Substances Data)

Usage

General Description

6-methyl-3-phenyl[1,2,4]triazolo[4,3-a]pyridine is a chemical compound with a complex molecular structure. It belongs to the class of triazolopyridine compounds and contains a methyl group and a phenyl group attached to a triazolopyridine ring. This chemical may have potential applications in pharmaceutical research and drug development due to its unique structure and properties. It could potentially be used as a building block for the synthesis of novel drug candidates or as a starting material for the development of new chemical entities. Further research and investigation are needed to fully understand the potential uses and properties of 6-methyl-3-phenyl[1,2,4]triazolo[4,3-a]pyridine.

Upstream product

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Relevant articles and documents

Electrochemical synthesis of 1,2,4-triazole-fused heterocycles

A reagent-free intramolecular dehydrogenative C-N cross-coupling reaction has been developed under mild electrolytic conditions. In this atom- and step-economical one-pot process, valuable 1,2,4-triazolo[4,3-a]pyridines and related heterocyclic compounds could be synthesized efficiently from commercially available aliphatic or (hetero)aromatic aldehydes and 2-hydrazinopyridines. Various functional groups are compatible with this metal- and oxidant-free protocol which can be carried out on a gram scale easily. This novel method was applied to the synthesis of one of the top-selling drugs Xanax and late stage functionalization for generating chemical diversity in biologically relevant lead molecules.

I2-TBHP-catalyzed one-pot highly efficient synthesis of 4,3-fused 1,2,4-triazoles from: N -tosylhydrazones and aromatic N-heterocycles via intermolecular formal 1,3-dipolar cycloaddition

I2-TBHP-catalyzed azomethine imine generation and subsequent regioselective 1,3-dipolar cycloaddition (DC) with aromatic N-heterocycles was developed to afford various 4,3-fused 1,2,4-triazoles in excellent yields. The method is operationally simple and highly efficient with broad functional group tolerance.

Synthesis of 1,2,4-Triazolo[4,3-a]pyridines and Related Heterocycles by Sequential Condensation and Iodine-Mediated Oxidative Cyclization

A facile and efficient approach to access 1,2,4-triazolo[4,3-a]pyridines and related heterocycles has been accomplished through condensation of readily available aryl hydrazines with corresponding aldehydes followed by iodine-mediated oxidative cyclizatio