4926-15-2

Basic information

• Product Name: 6-methyl-3-phenyl[1,2,4]triazolo[4,3-a]pyridine
• CAS NO: 4926-15-2
• Molecular Formula: C₁₃H₁₁N₃
• Molecular Weight: 209.2465
• Mol File: 4926-15-2.mol

Chemical Properties

• Density: 1.19g/cm³
• Refractive Index: 1.657
• CAS DataBase Reference: 6-methyl-3-phenyl[1,2,4]triazolo[4,3-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-3-phenyl[1,2,4]triazolo[4,3-a]pyridine(4926-15-2)
• EPA Substance Registry System: 6-methyl-3-phenyl[1,2,4]triazolo[4,3-a]pyridine(4926-15-2)

Safety Data

• Hazardous Substances Data: 4926-15-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
6-methyl-3-phenyl[1,2,4]triazolo[4,3-a]pyridine is used as a building block for the synthesis of novel drug candidates. Its unique molecular structure allows it to be a valuable component in the creation of new pharmaceutical compounds with potential therapeutic applications.
Used in Chemical Synthesis:
In the chemical synthesis industry, 6-methyl-3-phenyl[1,2,4]triazolo[4,3-a]pyridine is used as a starting material for the development of new chemical entities. Its specific structural features make it a promising candidate for further chemical modifications and innovations.
Further research and investigation are essential to fully explore the potential uses and properties of 6-methyl-3-phenyl[1,2,4]triazolo[4,3-a]pyridine, ensuring its safe and effective application in various fields.

Upstream product

• 108-99-6 3-Methylpyridine 
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• 4931-01-5 2-hydrazinyl-5-methylpyridine 
• 65-85-0 benzoic acid 

Relevant articles and documents

Electrochemical synthesis of 1,2,4-triazole-fused heterocycles

A reagent-free intramolecular dehydrogenative C-N cross-coupling reaction has been developed under mild electrolytic conditions. In this atom- and step-economical one-pot process, valuable 1,2,4-triazolo[4,3-a]pyridines and related heterocyclic compounds could be synthesized efficiently from commercially available aliphatic or (hetero)aromatic aldehydes and 2-hydrazinopyridines. Various functional groups are compatible with this metal- and oxidant-free protocol which can be carried out on a gram scale easily. This novel method was applied to the synthesis of one of the top-selling drugs Xanax and late stage functionalization for generating chemical diversity in biologically relevant lead molecules.

Synthesis method of 1,2,4-triazolohetercyclic compound

The invention provides a method for synthesizing a 1,2,4-triazolohetercyclic compound. The method comprises the following steps: dissolving a 2-hydrazinohetercyclic compound (I) and an aldehyde compound (II) into acetonitrile A; stirring at 25 DEG C to 80

I2-TBHP-catalyzed one-pot highly efficient synthesis of 4,3-fused 1,2,4-triazoles from: N -tosylhydrazones and aromatic N-heterocycles via intermolecular formal 1,3-dipolar cycloaddition

I2-TBHP-catalyzed azomethine imine generation and subsequent regioselective 1,3-dipolar cycloaddition (DC) with aromatic N-heterocycles was developed to afford various 4,3-fused 1,2,4-triazoles in excellent yields. The method is operationally simple and highly efficient with broad functional group tolerance.

RuCl3/Oxone: An efficient combination for the synthesis of 3-aryl-[1,2,4]triazolo[4,3-a]pyridines from 2-(2-arylidenehydrazinol)pyridines

An efficient and convenient method for the synthesis of 3-aryl[1,2,4]triazolo[4,3-a]pyridines has been developed involving RuCl3/Oxone oxidative cyclization of 2-(2-arylidenehydrazinyl)pyridines, which occurs chemoselectively at the pyridine ni

Synthesis of 1,2,4-Triazolo[4,3-a]pyridines and Related Heterocycles by Sequential Condensation and Iodine-Mediated Oxidative Cyclization

A facile and efficient approach to access 1,2,4-triazolo[4,3-a]pyridines and related heterocycles has been accomplished through condensation of readily available aryl hydrazines with corresponding aldehydes followed by iodine-mediated oxidative cyclizatio

A simple and efficient automatable one step synthesis of triazolopyridines from carboxylic acids

Triazolopyridines can be rapidly and efficiently synthesized from a variety of carboxylic acids with 2-hydrazinopyridines in one simple step. The use of commercially available PS-PPh3 resin combined with microwave heating delivered the product