494771-76-5

Basic information

• Product Name: 2-(4-Acetylpiperazino)-5-bromopyridine
• Synonyms: 2-(4-Acetylpiperazino)-5-bromopyridine;1-(4-(5-Bromopyridin-2-yl)piperazin-1-yl)ethanone;1-[4-(5-Bromo-2-pyridinyl)-1-piperazinyl]ethanone
• CAS NO: 494771-76-5
• Molecular Formula: C₁₁H₁₄BrN₃O
• Molecular Weight: 284.15236
• Mol File: 494771-76-5.mol

Chemical Properties

• Boiling Point: 447.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.469±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 6.06±0.29(Predicted)
• CAS DataBase Reference: 2-(4-Acetylpiperazino)-5-bromopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Acetylpiperazino)-5-bromopyridine(494771-76-5)
• EPA Substance Registry System: 2-(4-Acetylpiperazino)-5-bromopyridine(494771-76-5)

Safety Data

• Hazardous Substances Data: 494771-76-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(4-Acetylpiperazino)-5-bromopyridine is used as a reagent in the synthesis of various pharmaceutical drugs. Its unique structure and properties make it a valuable component in the development of new medications.
Used as a Brominating Agent:
In addition to its pharmaceutical applications, 2-(4-Acetylpiperazino)-5-bromopyridine can also function as a powerful brominating agent. This role is crucial in various chemical reactions and processes, where bromination is required to achieve specific outcomes or to synthesize particular compounds.

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 13889-98-0 N-acetylpiperidine 
• 108-24-7 acetic anhydride 
• 73406-97-0 5-bromo-2-(piperazin-1-yl)pyridine 

Relevant articles and documents

BENZENE OR THIOPHENE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR

The present invention provides a novel benzene derivative or thiophene derivative useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like, namely, a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof.

4-Amino-5-aryl-6-arylethynylpyrimidines: Structure-activity relationships of non-nucleoside adenosine kinase inhibitors

A series of non-nucleoside adenosine kinase (AK) inhibitors is reported. These inhibitors originated from the modification of 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine (ABT-702). The identification of a linker that would approximate the spatial arrangement found between the pyrimidine ring and the aryl group at C(7) in ABT-702 was a key element in this modification. A search of potential linkers led to the discovery of an acetylene moiety as a suitable scaffold. It was hypothesized that the aryl acetylenes, ABT-702, and adenosine bound to the active site of AK (closed form) in a similar manner with respect to the orientation of the heterocyclic base. Although potent acetylene analogs were discovered based on this assumption, an X-ray crystal structure of 5-(4-dimethylaminophenyl)-6-(6-morpholin-4-ylpyridin-3-ylethynyl)pyrimidin-4-ylamine (16a) revealed a binding orientation contrary to adenosine. In addition, this compound bound tightly to a unique open conformation of AK. The structure-activity relationships and unique ligand orientation and protein conformation are discussed.