73406-97-0

Usage

Uses

Used in Pharmaceutical Research:
5-BROMO-2-(PIPERAZIN-1-YL)PYRIDINE is used as a building block for the synthesis of various biologically active compounds, contributing to the development of new pharmaceuticals with potential therapeutic applications.
Used in Drug Development:
As a reagent, 5-BROMO-2-(PIPERAZIN-1-YL)PYRIDINE aids in the formulation and testing of novel drugs, enhancing the discovery of effective treatments for a range of diseases and conditions.
Used in Agrochemical Production:
5-BROMO-2-(PIPERAZIN-1-YL)PYRIDINE serves as a precursor in the creation of agrochemicals, supporting the development of new products designed to improve crop protection and yield.
Used in Coordination Chemistry:
The presence of the piperazine ring in 5-BROMO-2-(PIPERAZIN-1-YL)PYRIDINE makes it a potentially useful ligand in coordination chemistry, facilitating the synthesis of organometallic complexes with specific catalytic or binding properties.
Used in Medicinal Chemistry:
The bromine substituent in 5-BROMO-2-(PIPERAZIN-1-YL)PYRIDINE imparts unique reactivity to the molecule, which is valuable for the design and synthesis of new medicinal agents with improved pharmacological profiles.

InChI:InChI=1/C9H12BrN3/c10-8-1-2-9(12-7-8)13-5-3-11-4-6-13/h1-2,7,11H,3-6H2

Upstream product

• 153747-97-8 5-Bromo-2-(4-tert-butoxycarbonylpiperazin-1-yl)pyridine 
• 766-11-0 5-bromo-2-fluoropyridine 
• 110-85-0 piperazine 
• 53939-30-3 5-bromo-2-chloropyridine 
• 624-28-2 2,5-dibromopyridine 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 60-29-7 diethyl ether 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 153747-97-8 5-Bromo-2-(4-tert-butoxycarbonylpiperazin-1-yl)pyridine 
• 496786-98-2 2-(4-tert-butyloxycarbonyl-piperizin-1-yl)pyridine-5-boronic acid pinacol ester 
• 1359087-65-2 C₁₉H₂₃BrN₄O₄S 
• 1215010-54-0 2,6-dichloro-4-(6-(piperazin-1-yl)pyridin-3-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide 
• 494771-76-5 1-[4-(5-bromopyridin-2-yl)piperazin-1-yl]ethanone 
• 823197-35-9 1-[5-(benzyloxy)pyridin-2-yl]piperazine 

Relevant academic research and scientific papers

PYRAZOLOPYRIDINE COMPOUND AS RET INHIBITOR AND APPLICATION THEREOF

Disclosed is a series of pyrazolopyridine compounds, and application thereof in the preparation of RET kinase inhibitors for treatment. Specifically disclosed is the compound represented by formula (I), or a pharmaceutically acceptable salt thereof.

Pyrazolo[1, 5-a]pyridine compound, and preparation method and application thereof

The invention relates to a pyrazolo[1, 5-a]pyridine compound, a preparation method and application thereof, a pharmaceutical composition containing the compound as an active component, or a pharmaceutically acceptable salt of the compound. The invention further relates to application of the compound of formula (I) in the treatment and prophylaxis of diseases treatable with RET kinase inhibitors, including diseases or conditions mediated by RET kinases.

Substituted pyridine compound and its method and use thereof

The invention relates to a novel substitutive pyridine compound, and a pharmaceutically acceptable salt and a pharmaceutical preparation of the substitutive pyridine compound for regulating the activity of protein kinases and regulating signal responses between cells or in the cells. Meanwhile, the invention further relates to a pharmaceutical composition containing the compound provided by the invention, and a method for treating high proliferative diseases of mammals, especially human with the pharmaceutical composition.

PDE 10a Inhibitors for the Treatment of Type II Diabetes

Disclosed are compounds, compositions and methods for treating Type II diabetes. Such compounds are represented by Formula (I) as follows: wherein R1, R2, L, and Q are defined herein.

GLYCINE COMPOUND

[Problem] The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases. [Means for Solution] The present inventors have conducted intensive studies on a compound having a VAP-1 inhibitory activity, and as a result, they have found that a compound of the present invention or a salt thereof exhibits an excellent VAP-1 inhibitory activity and is useful for preventing and/or treating VAP-1-related diseases, in particular, diabetic nephropathy or diabetic macular edema, thereby completing the present invention. The present invention further relates to a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases, which comprises the compound of the present invention or a salt thereof, and an excipient.

NOVEL MEDICAMENTS

Novel compounds which interact with the histamine H3 receptor are defined. These compounds are particularly useful in the treatment of a variety of diseases or conditions in which histamine H3 interactions are beneficial. Thus, the compounds may find use, e.g., in the treatment of diseases of the central nervous system, the peripheral nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system. The novel compounds have a core consisting of a 6 membered aromatic ring containing at least one nitrogen atom and two carbon atoms in the ring and, at the remaining positions in the ring, there is either a carbon or a nitrogen atom.

HETEROCYCLYLAMIDE-SUBSTITUTED IMIDAZOLES

The invention relates to heterocyclylamide-substituted imidazoles and methods for the production of the same, to the use thereof for the treatment and/or prophylaxis of diseases, to the use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases, and especially to the use thereof as antiviral agents, especially against cytomegaloviruses.

N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF

The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof, in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.

Derivatives of 1-piperazine-and 1-homopiperazine-carboxylates, preparation method thereof and use of same as inhibitors of the FAAH enzyme

The invention relates to a compound having general formula (I): Wherein m, R1 and R2 are as defined herein. The invention also relates to the use of the compound in therapeutics. More specifically, the compounds of the invention are

2-Pyrimidineamine derivatives and processes for their preparation

Compounds of general formula (1) are described wherein: Ar is an optionally substituted aromatic group; R2 is a hydrogen or halogen atom or a group -X1-R2a where X1 is a direct bond or a linker atom or group, and R2a is an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group; R3 is an optionally substituted heterocycloalkyl group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are selective protein tyrosine kinase inhibitors, particularly the kinases ZAP-70 and syk and are of use in the prophylaxis and treatment of immune or allergic diseases and diseases involving inappropriate platelet activation.