- Preparation, characterization and biological activity of new tridentate imine-oxime ligand (H2L) and Its metal complexes
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The new tridentate Schiff-oxime ligand 1-[2-(2,4-dihydroxybenzylidene)aminophenyl]ethanone oxime (H2L), prepared via condensation of equal amounts of 1-(2-aminophenyl)ethanone oxime and 4-hydroxysalicylaldehyde. H2L ligand characterized by using FTIR, UV-
- Al-Zaidi, Basim H.,Ismail, Ahmed H.,Naseaf, Ali N.,Khamis, Wessal
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- Eco-friendly H2O2 oxidation of 1,2-dihydroquinazoline-3-oxides to quinazoline-3-oxides
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2-Aminobenzaldehyde, 1-(2-aminophenyl)ethanone, and 2-aminophenyl phenyl methanone oximes 1 were reacted with aromatic aldehydes to give the corresponding 1,2-dihydroquinazoline-3-oxides 2. The latter were converted in high yields to a series of quinazoli
- Samandram, Rashinikumar,?etin Koruk?u, Meliha,Co?kun, Necdet
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supporting information
p. 2349 - 2356
(2021/06/14)
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- A convenient approach to 2,4-disubstituted quinazoline-3-oxides using active MnO2 as the oxidant
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Using cheap, readily available, and economic active MnO2 as an oxidant, a series of 2,4-disubstituted quinazoline-3-oxides were synthesized in good to excellent yields by oxidation of the corresponding 1,2-dihydroquinazoline-3-oxides under mild
- Ye, Xinglin,Chen, Zhiyuan,Zhang, Zhipeng,Fu, Yang,Deng, Zhihong,Peng, Yiyuan
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supporting information
p. 682 - 689
(2019/09/06)
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- A advantage Ralli sandbank intermediate and its preparation method and application
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The present invention relates to a linagliptin intermediate, a preparation method and applications thereof, wherein the linagliptin intermediate has the structure represented by general formulas (II) and (IV), and X is halogen. According to the present invention, the compound of the present invention is the solid and has characteristics of low production cost, easy purification and easy storage, linagliptin can be efficiently prepared, and the method is suitable for industrial scale production.
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Paragraph 0115; 0118; 0121; 0122; 0123; 0124
(2017/08/25)
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- Visible light-mediated synthesis of quinazolines from 1,2- dihydroquinazoline 3-oxides
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A series of quinazolines were synthesized in good to excellent yields by exposing 1,2-dihydroquinazoline 3-oxides to visible light in acetonitrile without the presence of any external sensitizers. The only exception was the 2-(p-nitrophenyl)-substituted s
- Chen, Yi-Chou,Yang, Ding-Yah
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p. 10438 - 10444
(2013/11/19)
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- METHOD OF SYNTHESIZING 1H-INDAZOLE COMPOUNDS
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A method is provided for synthesizing 1H-indazole compounds in which aromatic carbonyl compounds are reacted with a nitrogen source to form oximes which are then converted to 1H-indazoles.
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Page/Page column 9
(2010/04/23)
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- An efficient synthesis of quinazolines: a theoretical and experimental study on the photochemistry of oxime derivatives
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A new photochemical method for the preparation of quinazolines (2) through irradiation of [2-(methyleneamino)phenyl]methanone oximes (1) is reported. The photoreaction has been studied in depth by experimental, theoretical and photochemical methods. A six-electron electrocyclic ring closure mechanism, followed by water loss, is proposed and rationalized to explain the formation of quinazolines (2).
- Alonso, Rafael,Caballero, Alegría,Campos, Pedro J.,Sampedro, Diego,Rodríguez, Miguel A.
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experimental part
p. 4469 - 4473
(2010/07/08)
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- A practical, metal-free synthesis of 1H-Lndazoles
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The synthesis of 1H-indazoles is achieved from o-aminobenzoximes by the selective activation of the oxime in the presence of the amino group. The reaction occurs with a variety of substituted o-aminobenzoximes using a slight excess of methanesulfonyl chloride and triethylamine at 0-23 °C and is amenable to scale-up. The synthesis of 1 H-indazoles under these conditions is extremely mild compared with previous synthetic approaches and affords the desired compounds in good to excellent yields.
- Counceller, Carla M.,Eichman, Chad C.,Wray, Brertda C.,Stambuli, James P.
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supporting information; experimental part
p. 1021 - 1023
(2009/04/07)
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- Mechanism of selective formation of 2-amino-substituted 1,4-benzodiazepin-4-oxides and 2-aminomethyl substituted quinazolin-3-oxides from chloromethyl quinazolin-N-oxides indications from perturbation theory
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The o-amino-acetophenone and -benzophenone oximes 1a-c react with chloroacetyl chloride giving the 2-chloromethyl-quinazoline-3-oxides 6a-c. The mechanism is explained using the perturbation theory. With ammonia and N-prim. aliphatic amines, compounds 6a-c yield 1,4-benzodiazepines 16 and 17 as ring-enlarged products, with aromatic and with N-sec. aliphatic amines, quinazoline derivatives 10-13 are formed. The constitution of the heterocycles is proved by nmr spectroscopic methods. Selective formation of the heterocyclic products is explained with the relative thermodynamic stability of the corresponding 2-adducts 14.
- Lessel
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- Algicidal and fungicidal 2-haloalkyl-3-oxo-4-substituted quinazoline
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2-Haloalkyl-3-oxo-4-substituted quinazolines represented by the formula STR1 wherein R is hydrogen, lower alkyl, lower alkyl substituted with one to three of the same or different halogens, phenyl or phenyl substituted with 1 to 3 of the same or different
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- Intramolecular Cyclization of Iminoxyl Radicals
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Iminyl radicals, generated by oxidation of the corresponding O-carboxymethoximes with persulfate, do not cyclise onto an ajacent azo group but the structurally related iminoxyls cyclise to give indazoles.ESR evidence is presented for the intramolecular ad
- Atmaram, Shiravanate,Forrester, Alexander R.,Gill, Melvyn,Napier, Russell J.,Thomson, Ronald H.
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p. 641 - 648
(2007/10/02)
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