- Alkylated Steroids. Part 3. The 21-Alkylation of 20-Oxopregnanes and Synthesis of a Novel Anti-inflammatory 16α,17α,21-Trimethyl Steroid (Org 6216)
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The development of a 21-alkylation reaction which proceeds via the lithium 20(21)-enolate is described and ats scope demonstrated by the preparation of a variety of 21-alkylpregnane derivatives.Application of this process to 11β-acetoxy-16α,17α-dimethyl-5α-pregnane-3,20-dione (28a) and its 5β-analogue (28b) led to the corresponding 16α,17α,21-trimethyl derivatives.Several routes from these saturated trimethylpregnane-3,20-diones to 11β-hydroxy-16α,17α,21-trimethylpregna-1,4-diene-3,20-dione (Org 6216) were explored.The best method gave Org 6216 in 75percent yield.
- Cairns, James,Logan, Robert T.,McGarry, George,Roy, Robert G.,Stevenson, Donald F. M.,Woods, Gilbert F.
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p. 2306 - 2316
(2007/10/02)
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