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49697-38-3

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49697-38-3

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Basic information
1. Product Name: RIMEXOLONE (100 MG)
2. Synonyms: RIMEXOLONE (100 MG);Rimexolone;(17S)-11β-Hydroxy-16α,17α-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one;11β-Hydroxy-16α,17α-dimethyl-17β-propionylandrosta-1,4-dien-3-one;Org-6216;(11b,16a,17b)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one;(11β,16α,17β)-;(11β, 16α, 17β)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androstra-1,4-dien-3-one
3. CAS NO:49697-38-3
4. Molecular Formula: C₂₄H₃₄O₃
5. Molecular Weight: 370.53
6. EINECS: N/A
7. Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
8. Mol File: 49697-38-3.mol
9. Article Data: 2
Chemical Properties
1. Melting Point: 258-268 ºC
2. Boiling Point: 507°Cat760mmHg
3. Flash Point: 274.5°C
4. Appearance: /
5. Density: 1.12
6. Vapor Pressure: 0mmHg at 25°C
7. Refractive Index: 1.561
8. Storage Temp.: N/A
9. Solubility: N/A
10. PKA: 14.42±0.70(Predicted)
11. CAS DataBase Reference: RIMEXOLONE (100 MG)(CAS DataBase Reference)
12. NIST Chemistry Reference: RIMEXOLONE (100 MG)(49697-38-3)
13. EPA Substance Registry System: RIMEXOLONE (100 MG)(49697-38-3)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 49697-38-3(Hazardous Substances Data)

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CAS:49697-38-3 Rimexolone
Cas No: 49697-38-3
USD $ 1.0-3.0 / Metric Ton
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Hebei yanxi chemical co.,LTD.
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High Quality 99% Rimexolone 49697-38-3 ISO Manufacturer
Cas No: 49697-38-3
USD $ 0.1-0.1 / Gram
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Xi'an Xszo Chem Co., Ltd.
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Rimexolone
Cas No: 49697-38-3
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Dayang Chem (Hangzhou) Co.,Ltd.
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Rimexolone
Cas No: 49697-38-3
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Chemwill Asia Co., Ltd.
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CAS 49697-38-3 Rimexolone
Cas No: 49697-38-3
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Hebei Nengqian Chemical Import and Export Co., LTD
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Discount priceCAS 49697-38-3 with competitive price
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Zhuozhou Wenxi import and Export Co., Ltd
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Hot Sell Factory Supply Raw Material CAS:49697-38-3 Rimexolone
Cas No: 49697-38-3
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Wuhan Han Sheng New Material Technology Co.，Ltd
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Rimexolone 49697-38-3
Cas No: 49697-38-3
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Shanghai Upbio Tech Co.,Ltd
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RIMEXOLONE (100 MG) CAS:49697-38-3
Cas No: 49697-38-3
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Qingdao Beluga Import and Export Co., LTD
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Rimexolone
Cas No: 49697-38-3
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Shandong Hanjiang Chemical Co., Ltd.
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49697-38-3 Usage

Description

Rimexolone, an ophthalmic corticosteroid, was launched in 1995 in the U.S.A. for the treatment of postoperative inflammation following ocular surgery and anterior uveitis. Rimexolone has high corticoid receptor affinity and is a potent local antiinflammatory agent with minimal systemic effects and virtually no atrophogenic action in many animal models studied, unique among a wide range of topical steroids. Rapid onset, long duration of action plus a superior safety profile are characteristics of rimexolone. It was also approved in Europe for the treatment of rheumatoid arthritis and is currently in clinical trials for tendinitis and osteoarthritis.

Originator

Akzo (Netherlands)

Uses

Anti-inflammatory (local).

Brand name

Vexol (Alcon).

General Description

Rimexolone, 11β-hydroxy-16α,17α-dimethyl-17-(1-oxopropyl)androsta-1,4-diene-3-one,like medrysone and fluorometholone, lacks the C21 OHgroup. In addition, rimexolone has an additional methylgroup in the 17 -position, a site where an OH group is typicallyfound. Rimexolone is available as a suspension forophthalmic use.

Check Digit Verification of cas no

The CAS Registry Mumber 49697-38-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,9,6,9 and 7 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 49697-38:
(7*4)+(6*9)+(5*6)+(4*9)+(3*7)+(2*3)+(1*8)=183
183 % 10 = 3
So 49697-38-3 is a valid CAS Registry Number.

InChI:InChI=1/C23H32O4/c1-13-10-17-16-7-6-14-11-15(24)8-9-21(14,2)19(16)18(25)12-22(17,3)23(13,4)20(26)27-5/h8-9,11,13,16-19,25H,6-7,10,12H2,1-5H3/t13-,16+,17+,18+,19-,21+,22+,23-/m1/s1

49697-38-3 Well-known Company Product Price

Brand
(Code)Product description
CAS number
Packaging
Price
Detail

USP
(1604600) Rimexolone United States Pharmacopeia (USP) Reference Standard
49697-38-3
1604600-100MG
4,662.45CNY
Detail

49697-38-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name	Rimexolone

1.2 Other means of identification

Product number	-
Other names	Asoprisnil ecamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:49697-38-3 SDS

49697-38-3Synthetic route

: 220983-31-3
11β-(trimethylsiloxy)-16α,17α,21-trimethylpregna-1,4-dien-3,20-dione

: 49697-38-3
rimexolone

Conditions

Conditions	Yield
With hydrogenchloride In methanol at 0 - 20℃; for 2.5h; Hydrolysis;	97%

: 50-24-8
prednisolon

: 49697-38-3
rimexolone

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1.1: pyridine / 5 °C 2.1: NaI / acetone / 20 °C 3.1: NaI; HOAc / acetone / Heating 4.1: 1.40 g / semicarbazide*HCl / H2O; acetic acid / 9.7 h / 80 - 85 °C 5.1: 1.42 g / DMAP; pyridine / 25 h 6.1: LiN(TMS)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.17 h / -65 - -60 °C 6.2: 82 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.03 h / -65 - 10 °C 7.1: 85.5 percent / CuCN / various solvent(s); tetrahydrofuran / 0.22 h / -45 °C 8.1: 63 percent / 4A molecular sieves; benzyltrimethylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C 9.1: 97 percent / aq. HCl / methanol / 2.5 h / 0 - 20 °C View Scheme

Yield

Multi-step reaction with 9 steps
1.1: pyridine / 5 °C
2.1: NaI / acetone / 20 °C
3.1: NaI; HOAc / acetone / Heating
4.1: 1.40 g / semicarbazide*HCl / H2O; acetic acid / 9.7 h / 80 - 85 °C
5.1: 1.42 g / DMAP; pyridine / 25 h
6.1: LiN(TMS)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.17 h / -65 - -60 °C
6.2: 82 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.03 h / -65 - 10 °C
7.1: 85.5 percent / CuCN / various solvent(s); tetrahydrofuran / 0.22 h / -45 °C
8.1: 63 percent / 4A molecular sieves; benzyltrimethylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C
9.1: 97 percent / aq. HCl / methanol / 2.5 h / 0 - 20 °C
View Scheme

: 49757-06-4
11β,17α-dihydoxy-21-iodopregna-1,4-diene-3,10-dione

: 49697-38-3
rimexolone

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1.1: NaI; HOAc / acetone / Heating 2.1: 1.40 g / semicarbazide*HCl / H2O; acetic acid / 9.7 h / 80 - 85 °C 3.1: 1.42 g / DMAP; pyridine / 25 h 4.1: LiN(TMS)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.17 h / -65 - -60 °C 4.2: 82 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.03 h / -65 - 10 °C 5.1: 85.5 percent / CuCN / various solvent(s); tetrahydrofuran / 0.22 h / -45 °C 6.1: 63 percent / 4A molecular sieves; benzyltrimethylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C 7.1: 97 percent / aq. HCl / methanol / 2.5 h / 0 - 20 °C View Scheme

Yield

Multi-step reaction with 7 steps
1.1: NaI; HOAc / acetone / Heating
2.1: 1.40 g / semicarbazide*HCl / H2O; acetic acid / 9.7 h / 80 - 85 °C
3.1: 1.42 g / DMAP; pyridine / 25 h
4.1: LiN(TMS)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.17 h / -65 - -60 °C
4.2: 82 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.03 h / -65 - 10 °C
5.1: 85.5 percent / CuCN / various solvent(s); tetrahydrofuran / 0.22 h / -45 °C
6.1: 63 percent / 4A molecular sieves; benzyltrimethylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C
7.1: 97 percent / aq. HCl / methanol / 2.5 h / 0 - 20 °C
View Scheme

: 110558-70-8
11β,17-dihydroxy-21-(toluene-4-sulfonyloxy)-pregna-1,4-diene-3,20-dione

: 49697-38-3
rimexolone

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1.1: NaI / acetone / 20 °C 2.1: NaI; HOAc / acetone / Heating 3.1: 1.40 g / semicarbazide*HCl / H2O; acetic acid / 9.7 h / 80 - 85 °C 4.1: 1.42 g / DMAP; pyridine / 25 h 5.1: LiN(TMS)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.17 h / -65 - -60 °C 5.2: 82 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.03 h / -65 - 10 °C 6.1: 85.5 percent / CuCN / various solvent(s); tetrahydrofuran / 0.22 h / -45 °C 7.1: 63 percent / 4A molecular sieves; benzyltrimethylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C 8.1: 97 percent / aq. HCl / methanol / 2.5 h / 0 - 20 °C View Scheme

Yield

Multi-step reaction with 8 steps
1.1: NaI / acetone / 20 °C
2.1: NaI; HOAc / acetone / Heating
3.1: 1.40 g / semicarbazide*HCl / H2O; acetic acid / 9.7 h / 80 - 85 °C
4.1: 1.42 g / DMAP; pyridine / 25 h
5.1: LiN(TMS)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.17 h / -65 - -60 °C
5.2: 82 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.03 h / -65 - 10 °C
6.1: 85.5 percent / CuCN / various solvent(s); tetrahydrofuran / 0.22 h / -45 °C
7.1: 63 percent / 4A molecular sieves; benzyltrimethylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C
8.1: 97 percent / aq. HCl / methanol / 2.5 h / 0 - 20 °C
View Scheme

: 20423-99-8
11β,17α-dihydroxypregna-1,4-diene-3,20-dione

: 49697-38-3
rimexolone

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: 1.40 g / semicarbazide*HCl / H2O; acetic acid / 9.7 h / 80 - 85 °C 2.1: 1.42 g / DMAP; pyridine / 25 h 3.1: LiN(TMS)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.17 h / -65 - -60 °C 3.2: 82 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.03 h / -65 - 10 °C 4.1: 85.5 percent / CuCN / various solvent(s); tetrahydrofuran / 0.22 h / -45 °C 5.1: 63 percent / 4A molecular sieves; benzyltrimethylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C 6.1: 97 percent / aq. HCl / methanol / 2.5 h / 0 - 20 °C View Scheme

Yield

Multi-step reaction with 6 steps
1.1: 1.40 g / semicarbazide*HCl / H2O; acetic acid / 9.7 h / 80 - 85 °C
2.1: 1.42 g / DMAP; pyridine / 25 h
3.1: LiN(TMS)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.17 h / -65 - -60 °C
3.2: 82 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.03 h / -65 - 10 °C
4.1: 85.5 percent / CuCN / various solvent(s); tetrahydrofuran / 0.22 h / -45 °C
5.1: 63 percent / 4A molecular sieves; benzyltrimethylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C
6.1: 97 percent / aq. HCl / methanol / 2.5 h / 0 - 20 °C
View Scheme

: 60124-50-7
11β-hydroxy-1,4,16-trienepregna-3,20-dione

: 49697-38-3
rimexolone

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: 1.42 g / DMAP; pyridine / 25 h 2.1: LiN(TMS)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.17 h / -65 - -60 °C 2.2: 82 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.03 h / -65 - 10 °C 3.1: 85.5 percent / CuCN / various solvent(s); tetrahydrofuran / 0.22 h / -45 °C 4.1: 63 percent / 4A molecular sieves; benzyltrimethylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C 5.1: 97 percent / aq. HCl / methanol / 2.5 h / 0 - 20 °C View Scheme

Yield

Multi-step reaction with 5 steps
1.1: 1.42 g / DMAP; pyridine / 25 h
2.1: LiN(TMS)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.17 h / -65 - -60 °C
2.2: 82 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.03 h / -65 - 10 °C
3.1: 85.5 percent / CuCN / various solvent(s); tetrahydrofuran / 0.22 h / -45 °C
4.1: 63 percent / 4A molecular sieves; benzyltrimethylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C
5.1: 97 percent / aq. HCl / methanol / 2.5 h / 0 - 20 °C
View Scheme

: 60124-51-8
11β-(trimethylsiloxy)-pregna-1,4,16-trien-3,20-dione

: 49697-38-3
rimexolone

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: LiN(TMS)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.17 h / -65 - -60 °C 1.2: 82 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.03 h / -65 - 10 °C 2.1: 85.5 percent / CuCN / various solvent(s); tetrahydrofuran / 0.22 h / -45 °C 3.1: 63 percent / 4A molecular sieves; benzyltrimethylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C 4.1: 97 percent / aq. HCl / methanol / 2.5 h / 0 - 20 °C View Scheme

Yield

Multi-step reaction with 4 steps
1.1: LiN(TMS)2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.17 h / -65 - -60 °C
1.2: 82 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.03 h / -65 - 10 °C
2.1: 85.5 percent / CuCN / various solvent(s); tetrahydrofuran / 0.22 h / -45 °C
3.1: 63 percent / 4A molecular sieves; benzyltrimethylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C
4.1: 97 percent / aq. HCl / methanol / 2.5 h / 0 - 20 °C
View Scheme

: 207346-24-5
21-methyl-11β-(trimethylsiloxy)-pregna-1,4,16-trien-3,20-dione

: 49697-38-3
rimexolone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 85.5 percent / CuCN / various solvent(s); tetrahydrofuran / 0.22 h / -45 °C 2: 63 percent / 4A molecular sieves; benzyltrimethylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C 3: 97 percent / aq. HCl / methanol / 2.5 h / 0 - 20 °C View Scheme

: 226712-41-0
16α,21-dimethyl-11β,20-bis(trimethylsiloxy)-pregna-1,4,17(20)-trien-3-one

: 49697-38-3
rimexolone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 63 percent / 4A molecular sieves; benzyltrimethylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C 2: 97 percent / aq. HCl / methanol / 2.5 h / 0 - 20 °C View Scheme

49697-38-3Upstream product

49697-38-3Downstream Products

49697-38-3Relevant articles and documents

Synthesis of the 16α,17α,21-trimethyl corticosteroid rimexolone from prednisolone

Conrow, Raymond E.

, p. 1042 - 1044 (2007/10/03)

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CAS

49697-38-3

49697-38-3

Basic information

Chemical Properties

Safety Data

49697-38-3 Suppliers

Recommended suppliersmore

49697-38-3 Usage

Description

Originator

Uses

Brand name

General Description

Check Digit Verification of cas no

49697-38-3 Well-known Company Product Price

49697-38-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

49697-38-3Synthetic route

49697-38-3Upstream product

49697-38-3Downstream Products

49697-38-3Relevant articles and documents

Synthesis of the 16α,17α,21-trimethyl corticosteroid rimexolone from prednisolone

Conrow, Raymond E.

, p. 1042 - 1044 (2007/10/03)