- External oxidant-free cross-coupling of arylcopper and alkynylcopper reagents leading to arylalkyne
-
External oxidant-free oxidative cross-coupling between arylcopper and alkynylcopper has been performed, which provides a new way for the formation of arylalkyne with high selectivity.
- Wang, Sheng,Min, Yaosen,Zhang, Xiaowei,Xi, Chanjuan
-
p. 28308 - 28312
(2017/07/07)
-
- Access to difluoromethylated alkynes through the castro-stephens reaction
-
An efficient synthesis of difluoromethylated alkynes is described. A panel of readily available CuI acetylides undergo direct difluoromethylation by using BrCF2CO2Et, which is an inexpensive, easy to handle, commercially available fluorinated reagent. The reaction, which is based on a Castro-Stephens transformation, proceeds smoothly under mild conditions offering a new synthetic route for the direct introduction of the difluoromethylated group into alkynes that does not involve ozone-depleting reagents. The resulting products were obtained with good yields by using CsOPiv and Cu(OAc)2 as additives.
- Besset, Tatiana,Poisson, Thomas,Pannecoucke, Xavier
-
p. 7220 - 7225
(2015/02/02)
-
- Tandem synthesis of 3-halo-5-substituted isoxazoles from 1-copper(I) alkynes and dihaloformaldoximes
-
A tandem synthesis of 3-halo-5-substituted isoxazoles has been developed from 1-copper(I) alkynes and dihaloformaldoximes under base-free conditions. Thus, 1,3-dipolar cycloaddition and all its drawbacks can now be avoided completely.
- Chen, Wenwen,Wang, Bo,Liu, Nan,Huang, Dayun,Wang, Xinyan,Hu, Yuefei
-
supporting information
p. 6140 - 6143
(2015/01/09)
-