497832-98-1

Basic information

• Product Name: 4-Bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole
• Synonyms: 4-BroMo-1-Methyl-5-(trifluoroMethyl)pyrazole;4-Bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole
• CAS NO: 497832-98-1
• Molecular Formula: C5H4BrF3N2
• Molecular Weight: 228.999
• Product Categories: Building Blocks;Pyrazole
• Mol File: 497832-98-1.mol

Chemical Properties

• Boiling Point: 200.4±35.0℃ (760 Torr)
• Flash Point: 75.0±25.9℃
• Appearance: /
• Density: 1.82±0.1 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: 4-Bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole(497832-98-1)
• EPA Substance Registry System: 4-Bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole(497832-98-1)

Safety Data

• Hazardous Substances Data: 497832-98-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole is utilized as a key intermediate in the synthesis of pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications, including those targeting various diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole serves as a precursor for the creation of bioactive molecules with pesticidal properties. Its incorporation into agrochemical products can contribute to the development of more effective and targeted pest control solutions.
Used in Materials Science:
4-Bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole has potential applications in materials science, where its specific chemical properties can be leveraged to create novel materials with unique characteristics for various industrial uses.
Used as a Reagent in Organic Synthesis:
4-Bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole also functions as a reagent in organic synthesis, facilitating specific chemical reactions that are crucial for the production of complex organic molecules, which can be used in a wide range of applications, from pharmaceuticals to specialty chemicals.

Upstream product

• 153085-15-5 1-methyl-5-(trifluoromethyl)-1H-pyrazole 

Downstream Products

• 497833-03-1 4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylic acid 
• 497833-04-2 1-methyl-5-trifluoromethyl-4-pyrazolecarbaldehyde 
• 7631-86-9 SiO₂ 
• 481065-92-3 1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylic acid 

Relevant articles and documents

Practical synthetic method for functionalized 1-methyl-3/5-(trifluoromethyl)-1H-pyrazoles

A new, high-yielding, and practical method for synthesis of 1-methyl-3-(trifluoromethyl)-1H-pyrazole and 1-methyl- 5-(trifluoromethyl)-1H-pyrazole, key intermediates for important building blocks relevant to medicinal and agrochemistry, is developed. A one-step procedure for synthesis of the regioisomeric mixture of target pyrazoles was proposed starting from 4-ethoxy- 1,1,1-trifluoro-3-buten-2-one. The procedure for separation of this mixture was elaborated on the basis of the boiling point vs pressure diagram analysis. The efficient synthetic strategies for regioisomeric building blocks bearing CF3 groups at the 3rd and 5th positions were demonstrated. A set of 1-methyl-3-(trifluoromethyl)-1H-pyrazoles containing such a functional group as aldehyde, acid, boron pinacolate, lithium sulfinate, and sulfonyl chloride was synthesized based on lithiation of 1-methyl-3-(trifluoromethyl)- 1H-pyrazole in a flow reactor. Bromination of both 1-methyl-3-(trifluoromethyl)-1H-pyrazole and 1-methyl-5-(trifluoromethyl)-1Hpyrazole by NBS in mild conditions was performed. The introduction of the functional group at the 4th position of 1-methyl-5- (trifluoromethyl)-1H-pyrazole was illustrated by the optimized synthesis of the corresponding aldehyde and acid based on the Br-Li exchange in an appropriate bromide. Alternatively, the introduction of the functional group (acid and boron pinacolate) at the 5th position of 1-methyl-5-(trifluoromethyl)-1H-pyrazole was performed based on the direct ortho-metalation (DoM) reaction of 4- bromo-1-methyl-5-(trifluoromethyl)pyrazole followed by catalytic reductive debromination.

Switchable reactivity: The site-selective functionalization of trifluoromethyl-substituted pyrazoles

Modern organometallic methods enable the regioflexible conversion of simple heterocyclic starting materials into families of isomers and congeners. Depending on the choice of the reagent, 1-methyl-5-(trifluoromethyl)pyrazole (1) undergoes deprotonation and subsequent carboxylation mainly or exclusively at either the 4-position of the heterocycle or at the nitrogen-attached methyl group. Similarly, 1-phenyl-5-(trifluoromethyl)pyrazole (5) and 3-methyl-l-phenyl-5-(trifluoromethyl)pyrazole (8) are selectively attacked by lithium diisopropylamide at the heterocyclic 4-position and by butyllithium concomitantly at the 4-position and the ortho position of the phenyl ring. In contrast, metalation of 1-methyl-3-(trifluoromethyl)pyrazole (2) occurs only at the 5-position, whatever the organometallic or metal amide base. Further sites become accessible to functionalization if bromine is introduced into the heterocyclic or aromatic ring. This has been demonstrated with 4-bromo-1-methyl-5-(trifluoromethyl)pyrazole (3), 4-bromo-l-methyl-3-(trifluoromethyl)pyrazole (4), 4-bromo-1-methyl-5-(trifluoromethyl)pyrazole (7) and 1-(2-bromophenyl)-5-(trifluoromethyl)pyrazole (6). Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.