- 2′-Substituted 1,1′-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them
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Compounds of the formula I, in which R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(8), R(30) and R(31) have the meanings indicated in the claims, are very particularly suitable as novel and antiarrythmic active compounds, in particular for the treatment and prophylaxis of atrial arrythmias, e.g. atrial fibrillation (AF), or atrial flutter.
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- Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kv1.5
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The voltage-gated potassium channel Kv1.5 is regarded as a promising target for the development of new atrial selective drugs with fewer side effects. In the present study the discovery of ortho, ortho-disubstituted bisaryl compounds as blockers of the Kv
- Peukert, Stefan,Brendel, Joachim,Pirard, Bernard,Brüggemann, Andrea,Below, Peter,Kleemann, Heinz-Werner,Hemmerle, Horst,Schmidt, Wolfgang
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p. 486 - 498
(2007/10/03)
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