- Preparation method of benorilate
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The invention relates to a preparation method of benorilate, which relates to the technical field of medicine synthesis. According to the invention, acetylsalicylic acid and acetaminophen are used asraw materials to directly synthesize behenolate under the condition of common catalysis of azodicarboxylic acid ester compounds and triphenylphosphine. The preparation method comprises the following steps: adding acetaminophen and a light-delay reaction catalyst I triphenylphosphine into a reaction bottle, adding an organic solvent, adding a light-delay reaction catalyst II, and uniformly mixing;and adding acetylsalicylic acid in batches within 20 minutes, stirring in an ice bath for 20 minutes, heating to normal temperature, magnetically stirring, and reacting for 8.5 hours to obtain the benorilate. According to the present invention, the acetylsalicylic acid and the p-acetamidophenol are catalyzed by using a light delay reaction catalysis system so as to be esterified, such that the steps are simple, the drugs only need to be sequentially added, the process route is short, and the synthesis cost is effectively reduced.
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Paragraph 0021-0037
(2020/05/05)
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