500372-26-9Relevant articles and documents
Design, synthesis and evaluation of novel P450 fluorescent probes bearing α-cyanoether
Zhang, Rong,Kang, Kyung-Don,Shan, Guomin,Hammock, Bruce D.
, p. 4331 - 4334 (2007/10/03)
Four α-cyano-containing ethers based on 2-alkoxy-2-naphthylacetonitriles have been designed as a novel structural class of cytochrome P450 fluorescent probes. Their syntheses, fluorescence properties and evaluation in the fluorogenic assay of cytochrome P
Cyanohydrin ethers and esters as high-sensitivity enzyme substrates
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, (2008/06/13)
Ethers and esters of cyanohydrins that contain optically detectable moieties are highly effective for detecting, monitoring, and measuring the activity of enzymes that cause the cleavage of certain types of substrates. The cyanohydrins function as proaldehydes and proketones, spontaneously converting to aldehydes and ketones, respectively, which provide a large increase in optical detectability relative to both the starting esters and ethers and the cyanohydrins.