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500775-82-6

8-chloro-2-phenylquinoline-4-carbonyl chloride is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 500775-82-6 Structure

  • Basic information

    1. Product Name: 8-chloro-2-phenylquinoline-4-carbonyl chloride
    2. Synonyms: 8-chloro-2-phenylquinoline-4-carbonyl chloride;4-quinolinecarbonyl chloride, 8-chloro-2-phenyl-
    3. CAS NO:500775-82-6
    4. Molecular Formula: C16H9Cl2NO
    5. Molecular Weight: 302.15476
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 500775-82-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 8-chloro-2-phenylquinoline-4-carbonyl chloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: 8-chloro-2-phenylquinoline-4-carbonyl chloride(500775-82-6)
    11. EPA Substance Registry System: 8-chloro-2-phenylquinoline-4-carbonyl chloride(500775-82-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 500775-82-6(Hazardous Substances Data)

500775-82-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 500775-82-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,0,7,7 and 5 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 500775-82:
(8*5)+(7*0)+(6*0)+(5*7)+(4*7)+(3*5)+(2*8)+(1*2)=136
136 % 10 = 6
So 500775-82-6 is a valid CAS Registry Number.

500775-82-6Relevant articles and documents

Phenylquinoline transient receptor potential vanilloid 1 antagonists for the treatment of pain: Discovery of 1-(2-phenylquinoline-4-carbonyl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide

Liao, Chen,Liu, Yan,Liu, Chunxia,Zhou, Jiaqi,Li, Huilan,Wang, Nasi,Li, Jieming,Liu, Taiyu,Ghaleb, Hesham,Huang, Wenlong,Qian, Hai

, p. 845 - 854 (2018/01/10)

Reported herein is the design, synthesis, and pharmacologic characterization of a class of TRPV1 antagonists constructed on a phenylquinoline platform that evolved from Cinchophen lead. This design composes three sections: a phenylquinoline headgroup attached to an aliphatic carboxamides, which is tethered at a phenyl tail group. Optimization of this design led to the identification of 37, comprising a pyrrolidine linker and a trifluoromethyl–phenyl tail. In the TRPV1 functional assay, using cells expressed hTRPV1, 37 antagonized capsaicin-induced Ca2+ influx, with an IC50 value of 10.2 nM. In the complete mice analgesic model, 37 exhibited better antinociceptive activity than the positive control BCTC in diverse pain models. All of these results suggested that 37 could be considered as a lead candidate for the further development of antinociceptive drugs.

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