500797-85-3

Basic information

• Product Name: 2-Bromo-6-chloro-9H-purine
• Synonyms: 2-Bromo-6-chloro-9H-purine;2-bromo-6-chloro-7H-purine
• CAS NO: 500797-85-3
• Molecular Formula: C5H2BrClN4
• Molecular Weight: 233.45318
• Mol File: 500797-85-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Bromo-6-chloro-9H-purine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-6-chloro-9H-purine(500797-85-3)
• EPA Substance Registry System: 2-Bromo-6-chloro-9H-purine(500797-85-3)

Safety Data

• Hazardous Substances Data: 500797-85-3(Hazardous Substances Data)

Upstream product

• 10310-21-1 2-amino-6-chloropurine 
• 470483-92-2 9-acetyl-2-amino-6-chloro-9H-purine 

Relevant articles and documents

COMPOUNDS FOR TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS

Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I" and I'" or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.

Synthesis of some biologically active halogenopurines

A series of some biologically active halogenopurines were synthesized from commercially available guanine (1). The reaction of guanine with acetic anhydride yielded 2,9-diacetylguanine (2-1) by acetylation reaction. Further treatment of 2-1 with POCl3 by PEG-2000 phase transfer catalysis furnished the important compound 3a, then 2-amino-6-halogenopurines (3b-d) were obtained through chlorine-exchange halogenations between KX and 3a by TPPB phase transfer catalyst. Further, 2-halogenopurines (2-2a-d, 4-2a-d, 5a-d) were efficiently prepared from 2-amino-6-substituted purines (1, 3a, 4-1) via a diazotization catalyzed by their corresponding CuX, and some new compounds 2-2a, 2-2c, 2-2d, 4-2c, 4-2d, 5b, 5c and 5d have been discovered. The structures of synthesized compounds were mainly established on the basis of their elemental analysis, 1H NMR, as well as their mass spectral data. All the title compounds were screened for their antifungal activities, and some of the compounds showed promising activity.

PRODUCTION METHOD OF 2,6-DIHALOPURINE

By reacting the compound of the formula [Ia] or [Ib] with halosilane compound and an agent for diazo reaction, 2,6-dihalopurine of the formula [II] can be produced conveniently in a high yield and can be easily isolated.wherein each symbol is as defined in the specification.