- Antiarrhythmic agents based on diterpenoid alkaloids
-
Diterpenoid alkaloids comprise a large group of natural compounds produced by the plants of the genera Aconitum and Delphinium. Some of these compounds were found to manifest valuable pharmacological properties, including the unique antiarrhythmic activity. Allapinine (derived from the alkaloid lappaconitine) was approved as a drug. The investigation of the structure-activity relationship revealed structural elements responsible for the arrhythmogenic and antiarrhythmic properties.
- Yunusov
-
scheme or table
p. 633 - 638
(2012/02/06)
-
- Five new napelline-type diterpene alkaloids from Aconitum liangshanium
-
The structures of five new C20-diterpene alkaloids having the napelline skeleton, i.e., 12-epi-lucidusculine (2), 12-epi-19-dehydronapelline (8), 12-epi-19-dehydrolucidusculine (9), liangshanine (3), and liangshanone (11), found from the roots of Aconitum liangshanium, were determined by spectroscopic analysis and chemical reactions.
- Takayama,Wu,Eda,Oda,Aimi,Sakai
-
p. 1644 - 1646
(2007/10/02)
-
- ALKALOIDS OF THE EPIGEAL PART OF Aconitum karakolicum. THE STRUCTURE OF 12-EPINAPELLINE
-
A new alkaloid has been isolated from the eipgeal part of the Aconitum karakolicum Rapaics. and has been called 12-epinapelline.The structure of the new alkaloid has been shown by the preparation of a diacetate and an iso derivative and also by the direct passage from songorine to 12-epinapelline and a study of their spectral characteristics.
- Sultankhodzhaev, M. N.,Yunusov, M. S.
-
p. 319 - 321
(2007/10/02)
-